Evidence map›Paper›PMID 20418657›Full record

Trial reportPrion

Reduction of PrP(C) in human cerebrospinal fluid after spinal cord injury.

Anna Carnini, Steve Casha, V Wee Yong, R John Hurlbert, Janice E A Braun

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Prion. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. The Role of Shed PrPJournal of immunology (Baltimore, Md. : 1950) · 2017
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna CarniniHotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, AL, CA.
Steve Casha
V Wee Yong
R John Hurlbert
Janice E A Braun
University of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been estimated that cerebrospinal fluid (CSF) contains approximately 80 proteins that significantly increase or decrease in response to various clinical conditions. Here we have evaluated the CSF protein PrP(C) (cellular prion protein) for possible increases or decreases following spinal cord injury. The physiological function of PrP(C) is not yet completely understood; however, recent findings suggest that PrP(C) may have neuroprotective properties. Our results show that CSF PrP(C) is decreased in spinal cord injured patients 12 h following injury and is absent at 7 days. Given that normal PrP(C) has been proposed to be neuroprotective we speculate that the decrease in CSF PrP(C) levels may influence neuronal cell survival following spinal cord injury.

Indexed as

14-3-3 ProteinsAdolescentAdultAgedAged, 80 and overBlotting, WesternCatheters, IndwellingCerebrospinal Fluid PressureCrystallinsFemaleHeat-Shock ProteinsHumansImmunoglobulin GMaleMiddle AgedMinocycline14-3-3 ProteinsCrystallinsHeat-Shock ProteinsImmunoglobulin GMinocyclineMolecular ChaperonesPrPC Proteins

Identifiers

PMID20418657
PMCPMC2933055
OpenAlexW2066048879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.