ReviewJournal of endocrinological investigation2010
Growth hormone/insulin-like growth factor-I axis in obstructive sleep apnea syndrome: an update.
Review in Journal of endocrinological investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Growth and sleep outcomes after adenotonsillectomy in pediatric mild sleep-disordered breathing.Scientific reports · 2025Trial
- Higher prevalence of short stature and excess weight in children with sleep disorders.Frontiers in endocrinology · 2025Article
- REM-OSA as a Tool to Understand Both the Architecture of Sleep and Pathogenesis of Sleep Apnea-Literature Review.Journal of clinical medicine · 2023Review
- Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia.Biomedicines · 2022Review
- The effect of central growth hormone action on hypoxia ventilatory response in conscious mice.Brain research · 2022Article
- The Adjuvant Therapy of Intravenous Laser Irradiation of Blood (ILIB) on Pain and Sleep Disturbance of Musculoskeletal Disorders.Journal of personalized medicine · 2022Article
- Reduced circulating growth hormone and insulin-like growth factor-1 and delayed growth of premature rats are aggravated by longer daily duration of chronic intermittent hypoxia exposure.Frontiers in pediatrics · 2022Article
- The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels.Disease markers · 2021Article
- Serum concentrations of insulin-like growth factor-1 as a biomarker of improved circadian rhythm sleep-wake disorder in school-aged children.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Association between obstructive sleep apnea and lipid metabolism during REM and NREM sleep.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- A Suggested Role of Human Growth Hormone in Control of the COVID-19 Pandemic.Frontiers in endocrinology · 2020Article
- The Somatotropic Axis in the Sleep Apnea-Obesity Comorbid Duo.Frontiers in endocrinology · 2020Article
- Article
- Adherence to the Mediterranean Diet is Associated with Better Sleep Quality in Italian Adults.Nutrients · 2019Article
- Arousal index as a marker of carotid artery atherosclerosis in patients with obstructive sleep apnea syndrome.Sleep & breathing = Schlaf & Atmung · 2019Article
- Achondroplasia: a comprehensive clinical review.Orphanet journal of rare diseases · 2019Review
- IGF-1 Levels are Inversely Associated With Metabolic Syndrome in Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Article
- Association between Serum IGF-I levels and Postoperative Delirium in Elderly Subjects Undergoing Elective Knee Arthroplasty.Scientific reports · 2016Article
- Sleep apnea syndrome in endocrine clinics.Journal of endocrinological investigation · 2015Review
- Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain.BMC medical genomics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnea syndrome (OSAS) is a serious, prevalent condition that has significant mortality and morbidity when untreated. It is strongly associated with obesity and is characterized by changes in the serum levels or secretory patterns of several hormones. In particular, obese patients with OSAS show a peculiar reduction of both spontaneous and stimulated GH secretion coupled with reduced IGF-I concentrations and impaired peripheral sensitivity to GH. These endocrine abnormalities are more marked than those observed in non-apneic obese subjects, and are likely to be due to the effects of hypoxia and sleep fragmentation on hormone secretory pattern. The GH/IGF-I axis activity disruption can be responsible, at least in part, for metabolic alterations, which are common in OSAS and increase the risk of cardiovascular events as well as mortality. Effective assessment and management of OSAS may correct endocrine changes, improve quality of life, and prevent associated morbidity or death.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.