ArticleSchizophrenia bulletin2010
Neural changes associated with relational learning in schizophrenia.
Article in Schizophrenia bulletin, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Transcranial direct current stimulation and cognitive training in the treatment of cognitive deficit in schizophrenia: a randomized controlled trial.BMC psychiatry · 2026Trial
- Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers.Current topics in behavioral neurosciences · 2023Article
- Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical review.World journal of psychiatry · 2017Article
- Transitive inference deficits in unaffected biological relatives of schizophrenia patients.Schizophrenia research · 2016Article
- Aberrant Hippocampal Connectivity in Unmedicated Patients With Schizophrenia and Effects of Antipsychotic Medication: A Longitudinal Resting State Functional MRI Study.Schizophrenia bulletin · 2016Article
- Effectiveness of fast mapping to promote learning in schizophrenia.Schizophrenia research. Cognition · 2016Article
- Practice and Learning: Spatiotemporal Differences in Thalamo-Cortical-Cerebellar Networks Engagement across Learning Phases in Schizophrenia.Frontiers in psychiatry · 2016Article
- Task-independent effects are potential confounders in longitudinal imaging studies of learning in schizophrenia.NeuroImage. Clinical · 2016Article
- Facilitation of relational learning in schizophrenia.Behavioral sciences (Basel, Switzerland) · 2013Article
- Learning and memory depend on fibroblast growth factor receptor 2 functioning in hippocampus.Biological psychiatry · 2012Article
- Impaired associative inference in patients with schizophrenia.Schizophrenia bulletin · 2012Article
- Spatial memory deficits in a virtual reality eight-arm radial maze in schizophrenia.Schizophrenia research · 2012Article
- Bilateral hippocampal dysfunction in schizophrenia.NeuroImage · 2011Article
- Successful learning in schizophrenia, functional neuroimaging studies, and theoretical considerations.Schizophrenia bulletin · 2010Article
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5 authors.
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Abstract
Relational learning, which is learning the relationship among items, is impaired in schizophrenia but can be improved with training. This study investigated neural changes with functional magnetic resonance imaging before and after training on a relational learning task in schizophrenia and healthy control subjects. Despite their acquiring similar relational learning performance, the groups exhibited different neural activation patterns before and following training. Controls engaged regions within the relational learning network that included frontal, parietal, and medial temporal lobe, before and following training. Controls also exhibited activation reductions in region and spatial extent with relational learning proficiency, a commonly observed phenomenon in successful learning. In contrast, subjects with schizophrenia displayed no positive activations compared with the control condition before training. After training, subjects with schizophrenia displayed bilateral inferior parietal region activation as predicted. Contrary to hypothesis, hippocampal activation was not observed following training in schizophrenia. These findings suggest that the parietal lobe may be receptive to cognitive training interventions and that successful relational learning may be achieved in schizophrenia through the use of alternative extrahippocampal brain regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.