Evidence map›Paper›PMID 20418396›Full record

ArticleJournal of bacteriology2010

YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli.

S James L Cariss, Chrystala Constantinidou, Mala D Patel, Yuiko Takebayashi, Jon L Hobman, Charles W Penn, Matthew B Avison

Abstract read
In one paragraph

Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

S James L CarissDepartment of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom.
Chrystala Constantinidou
Mala D Patel
Yuiko Takebayashi
Jon L Hobman
Charles W Penn
Matthew B Avison

Funding

Biotechnology and Biological Sciences Research Council BB/C514266/1Biotechnology and Biological Sciences Research Council EGA16107Biotechnology and Biological Sciences Research Council JIF13209
6 · The paper itself

Abstract

Colicin E2-tolerant (known as Cet2) Escherichia coli K-12 mutants overproduce an inner membrane protein, CreD, which is believed to cause the Cet2 phenotype. Here, we show that overproduction of CreD in a Cet2 strain results from hyperactivation of the CreBC two-component regulator, but CreD overproduction is not responsible for the Cet2 phenotype. Through microarray analysis and gene knockout and overexpression studies, we show that overexpression of another CreBC-regulated gene, yieJ (also known as cbrC), causes the Cet2 phenotype.

Indexed as

ColicinsEscherichia coli K12Escherichia coli ProteinsGene Expression Regulation, BacterialOligonucleotide Array Sequence AnalysisReverse Transcriptase Polymerase Chain ReactionColicinsEscherichia coli Proteins

Identifiers

PMID20418396
PMCPMC2897664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.