ArticleChemical senses2010
Mouse urinary biomarkers provide signatures of maturation, diet, stress level, and diurnal rhythm.
Article in Chemical senses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Partial role of volatile organic compounds in behavioural responses of mice to bedding from cancer-affected congeners.Biology open · 2024Article
- CFA-treated mice induce hyperalgesia in healthy mice via an olfactory mechanism.European journal of pain (London, England) · 2024Article
- Urinary VOCs as biomarkers of early stage lung tumour development in mice.Cancer biomarkers : section A of Disease markers · 2024Article
- Ants act as olfactory bio-detectors of tumours in patient-derived xenograft mice.Proceedings. Biological sciences · 2023Article
- Pheromones that correlate with reproductive success in competitive conditions.Scientific reports · 2021Article
- Assessing urinary odours across the oestrous cycle in a mouse model using portable and benchtop gas chromatography-mass spectrometry.Royal Society open science · 2021Article
- Article
- Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice.Frontiers in molecular biosciences · 2018Article
- Host stress hormones alter vector feeding preferences, success, and productivity.Proceedings. Biological sciences · 2016Article
- Alterations of the volatile metabolome in mouse models of Alzheimer's disease.Scientific reports · 2016Article
- Extracting Social Information from Chemosensory Cues: Consideration of Several Scenarios and Their Functional Implications.Frontiers in neuroscience · 2015Article
- Online breath gas analysis in unrestrained mice by hs-PTR-MS.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
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Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Body fluids such as urine potentially contain a wealth of information pertaining to age, sex, social and reproductive status, physiologic state, and genotype of the donor. To explore whether urine could encode information regarding environment, physiology, and development, we compared the volatile compositions of mouse urine using solid-phase microextraction and gas chromatography-mass spectrometry (SPME-GC/MS). Specifically, we identified volatile organic compounds (VOCs) in individual urine samples taken from inbred C57BL/6J-H-2(b) mice under several experimental conditions-maturation state, diet, stress, and diurnal rhythms, designed to mimic natural variations. Approximately 1000 peaks (i.e., variables) were identified per comparison and of these many were identified as potential differential biomarkers. Consistent with previous findings, we found groups of compounds that vary significantly and consistently rather than a single unique compound to provide a robust signature. We identified over 49 new predictive compounds, in addition to identifying several published compounds, for maturation state, diet, stress, and time-of-day. We found a considerable degree of overlap in the chemicals identified as (potential) biomarkers for each comparison. Chemometric methods indicate that the strong group-related patterns in VOCs provide sufficient information to identify several parameters of natural variations in this strain of mice including their maturation state, stress level, and diet.
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Registered trials
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