ReviewInnate immunity2010
Review: Collectins link innate and adaptive immunity in allergic airway disease.
Review in Innate immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The Immune Modulatory Role of Surfactants inJournal of inflammation research · 2025Review
- The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung.PloS one · 2024Article
- Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells.Frontiers in immunology · 2022Article
- Surfactant protein A modulates the activities of the JAK/STAT pathway in suppressing Th1 and Th17 polarization in murine OVA-induced allergic asthma.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Research article expression of surfactant protein-A and D, and CD9 in lungs of 1 and 30 day old foals.BMC veterinary research · 2021Article
- Autophagy proteins are required for club cell structure and function in airways.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Biomarkers of respiratory allergy in laboratory animal care workers: an observational study.International archives of occupational and environmental health · 2018Observational
- The Emerging Roles of Surfactant Protein-A in Asthma.Journal of clinical & cellular immunology · 2018Article
- Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver.Science (New York, N.Y.) · 2017Article
- Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Surfactant protein-A suppresses eosinophil-mediated killing of Mycoplasma pneumoniae in allergic lungs.PloS one · 2012Article
- Surfactant and its role in the pathobiology of pulmonary infection.Microbes and infection · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Although the lipoprotein complex of pulmonary surfactant has long been recognized as essential for reducing lung surface tension, its role in lung immune host defense has only relatively recently been elucidated. Surfactant-associated proteins A (SP-A) and D (SP-D) can attenuate bacterial and viral infection and inflammation by acting as opsonins and by regulating innate immune cell functions. Surfactant-associated protein A and D also interact with antigen-presenting cells and T cells, thereby linking the innate and adaptive immune systems. A recent study from our laboratory demonstrated that mice deficient in SP-A have enhanced susceptibility to airway hyper-responsiveness and lung inflammation induced by Mycoplasma pneumonia, an atypical bacterium present in the airways of approximately 50% of asthmatics experiencing their first episode, and further supports an important role for SP-A in the host response to allergic airway disease. Animal and human studies suggest that alterations in the functions or levels of SP-A and SP-D are associated with both infectious and non-infectious chronic lung diseases such as asthma. Future studies are needed to elucidate whether alterations in SP-A and SP-D are a consequence and/or cause of allergic airway disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.