Evidence map›Paper›PMID 20418245›Full record

ArticleHaematologica2010

Aggressive large B-cell lymphoma with plasma cell differentiation: immunohistochemical characterization of plasmablastic lymphoma and diffuse large B-cell lymphoma with partial plasmablastic phenotype.

Santiago Montes-Moreno, Ana-Rosa Gonzalez-Medina, Socorro-María Rodriguez-Pinilla, Lorena Maestre, Lydia Sanchez-Verde, Giovanna Roncador, Manuela Mollejo, Juan F García, Javier Menarguez, Carlos Montalbán and 3 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.

  1. CD20-negative diffuse large B cell lymphoma: a comprehensive analysis of 695 cases.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Santiago Montes-MorenoLymphoma Group, Molecular Pathology Programme Spanish National Cancer Research Centre, CNIO, Madrid, Spain. smontes@cnio.es
Ana-Rosa Gonzalez-Medina
Socorro-María Rodriguez-Pinilla
Lorena Maestre
Lydia Sanchez-Verde
Giovanna Roncador
Manuela Mollejo
Juan F García
Javier Menarguez
Carlos Montalbán
M Carmen Ruiz-Marcellan
Eulogio Conde
Miguel A Piris
Spanish National Cancer Research Centre · ESHospital General De Segovia · ESHospital General Universitario Gregorio Marañón · ESHospital Universitario Ramón y Cajal · ESHospital Virgen de la Salud · ESMarqués de Valdecilla University Hospital · ESThe University of Texas MD Anderson Cancer Center · USVall d'Hebron Hospital Universitari · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlasmablastic lymphoma has recently come to be considered a distinct entity among mature B cell neoplasms, although the limits with diffuse large B-cell lymphoma (DLBCL) need to be more accurately defined. DESIGN AND

methodsHere we show the results of an immunohistochemical study of 35 cases of plasmablastic lymphoma compared with a set of 111 conventional DLBCLs.

resultsOur results demonstrate that the use of a limited combination of immunohistochemical markers (PAX5&CD20, PRDM1/BLIMP1 and XBP1s) enables the identification of a plasmablastic immunophenotype highly characteristic of plasmablastic lymphoma cases and associated with an aggressive clinical behavior. Additionally, the study shows that the acquisition of a partial plasmablastic phenotype (PRDM1/BLIMP1 expression) in DLBCL is associated with shorter survival in R-CHOP-treated patients.

conclusionsThe use of a restricted combination of immunohistochemical markers (PAX5&CD20, PRDM1/BLIMP1 and XBP1s) enables a more accurate definition of terminal differentiation for large B-cell lymphoma.

Indexed as

AdultAgedAged, 80 and overAntigens, CD20Antineoplastic Combined Chemotherapy ProtocolsCell DifferentiationFemaleHumansImmunohistochemistryImmunophenotypingLymphoma, B-CellLymphoma, Large B-Cell, DiffuseMaleMiddle AgedNeoplasm StagingPAX5 Transcription FactorAntigens, CD20PAX5 protein, humanPAX5 Transcription FactorPositive Regulatory Domain I-Binding Factor 1PRDM1 protein, humanRepressor Proteins

Identifiers

PMID20418245
PMCPMC2913083
OpenAlexW2165916793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.