ArticleEnvironmental health perspectives2010
Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Benzene exposure and non-Hodgkin lymphoma: a systematic review and meta-analysis of human studies.The Lancet. Planetary health · 2021Pooled it
- Pooled it
- Combined effects of thermal stress and benzene or toluene exposure on the immune and reproductive disruption in Nile tilapia (Oreochromis niloticus).Scientific reports · 2026Article
- Influence of psychosocial work factors on male fertility and sperm quality: a scoping review.Reproductive biology and endocrinology : RB&E · 2025Article
- Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation.Scandinavian journal of work, environment & health · 2024Article
- Leukemia risk assessment of exposure to low-levels of benzene based on the linearized multistage model.Frontiers in public health · 2024Article
- Multi- and Transgenerational Effects of Environmental Toxicants on Mammalian Reproduction.Cells · 2022Review
- Molecular Alterations and Severe Abnormalities in Spermatozoa of Young Men Living in the "Valley of Sacco River" (Latium, Italy): A Preliminary Study.International journal of environmental research and public health · 2022Article
- Benzene exposure increases the risk of non-Hodgkin's lymphoma: a systematic review and meta-analysis of observational studies.Translational cancer research · 2022Article
- Environmental and occupational exposures associated with male infertility.Arhiv za higijenu rada i toksikologiju · 2021Review
- Sperm Aneuploidy in Faroese Men with Lifetime Exposure to Dichlorodiphenyldichloroethylene (p,p´-DDE) and Polychlorinated Biphenyl (PCB) Pollutants.Environmental health perspectives · 2016Article
- Air quality in the Industrial Heartland of Alberta, Canada and potential impacts on human health.Atmospheric environment (Oxford, England : 1994) · 2013Article
- Environmental exposure to polychlorinated biphenyls and p,p'-DDE and sperm sex-chromosome disomy.Environmental health perspectives · 2012Article
- Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men.Environmental health perspectives · 2012Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBenzene is a common industrial chemical known to induce leukemia and other blood disorders, as well as aneuploidy, in both human blood cells and sperm at exposures > 10 ppm. Recent reports have identified health effects at exposure levels < 1 ppm, the permissible exposure limit (PEL; 8 hr) set by the U.S. Occupational Safety and Health Administration.
objectiveWe investigated whether occupational exposures to benzene near 1 ppm induce aneuploidy in sperm.
methodsWe used multicolor fluorescence in situ hybridization to measure the incidence of sperm with numerical abnormalities of chromosomes X, Y, and 21 among 33 benzene-exposed men and 33 unexposed men from Chinese factories. Individual exposures were assessed using personal air monitoring and urinary concentrations of benzene and trans,trans-muconic acid (E,E-MA). Air benzene concentrations were not detectable in unexposed men; in exposed men, concentrations ranged from below the detection limit to 24 ppm (median, 2.9 ppm), with 27% of exposed men (n = 9) having concentrations of <or= 1 ppm. Exposed men were categorized into low and high groups based on urinary E,E-MA (median concentrations of 1.9 and 14.4 mg/L, respectively; median air benzene of 1 and 7.7 ppm, respectively), and aneuploidy frequencies were compared with those of unexposed men.
resultsSperm aneuploidy increased across low- and high-exposed groups for disomy X [incidence rate ratio (IRR) = 2.0; 95% confidence interval (CI), 1.1-3.4; and IRR = 2.8; 95% CI, 1.5-4.9, respectively], and for overall hyperhaploidy for the three chromosomes investigated (IRR = 1.6; 95% CI, 1.0-2.4; and IRR = 2.3; 95% CI, 1.5-3.6, respectively). We also found elevated disomy X and hyperhaploidy in the nine men exposed to <or= 1 ppm benzene compared with unexposed men (IRR = 1.8; 95% CI, 1.1-3.0; and IRR = 2.0; 95% CI, 1.1-3.9, respectively).
conclusionsBenzene appeared to increase the frequencies of aneuploid sperm for chromosomes associated with chromosomal abnormality syndromes in human offspring, even in men whose air benzene exposure was at or below the U.S. permissible exposure limit.
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