ArticleBrain and language2010
Longitudinal cerebral blood flow changes during speech in hereditary ataxia.
Article in Brain and language, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- ClearSpeechTogether: a Rater Blinded, Single, Controlled Feasibility Study of Speech Intervention for People with Progressive Ataxia.Cerebellum (London, England) · 2023Article
- Altered cerebral blood flow in patients with spinocerebellar degeneration.Frontiers in neuroscience · 2022Article
- Cerebral Blood Flow Is Not a Direct Surrogate of Behavior: Performance Models Suggest a Role for Functional Meta-Networks.Frontiers in neuroscience · 2022Article
- Genotypic Differences in Networks Supporting Regional Predictors of Speech Rate in Spinocerebellar Ataxia: Preliminary Observations.Brain connectivity · 2021Article
- Stimulation of the Subthalamic Nucleus Changes Cortical-Subcortical Blood Flow Patterns During Speech: A Positron Emission Tomography Study.Frontiers in neurology · 2021Article
- Performance and Function Meet Structure: A White Matter Connection Tuned for Vocal Production.Brain connectivity · 2018Article
- Cortical-subcortical production of formulaic language: A review of linguistic, brain disorder, and functional imaging studies leading to a production model.Brain and cognition · 2018Review
- Switching Language Modes: Complementary Brain Patterns for Formulaic and Propositional Language.Brain connectivity · 2018Article
- The Affective Nature of Formulaic Language: A Right-Hemisphere Subcortical Process.Frontiers in neurology · 2018Article
- Functional connectivity associated with acoustic stability during vowel production: implications for vocal-motor control.Brain connectivity · 2015Article
- Spatiotemporal linear mixed effects modeling for the mass-univariate analysis of longitudinal neuroimage data.NeuroImage · 2013Article
- Statistical analysis of longitudinal neuroimage data with Linear Mixed Effects models.NeuroImage · 2013Article
- Performance-based connectivity analysis: a path to convergence with clinical studies.NeuroImage · 2012Article
- Speech characteristics associated with three genotypes of ataxia.Journal of communication disordersArticle
Corrections and comments
- Erratum issuedNaoum, Ansam [corrected to Groshong, Ansam]
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
The hereditary ataxias constitute a group of degenerative diseases that progress over years or decades. With principal pathology involving the cerebellum, dysarthria is an early feature of many of the ataxias. Positron emission tomography was used to study regional cerebral blood flow changes during speech production over a 21 month period in a group of seven right-handed subjects with hereditary ataxia (6 females and 1 male, 3 SCA1 and 4 SCA5, aged 38.3+/-18.9 years). The decline in blood flow was greatest in cerebellar regions. In contrast, blood flow actually increased during speech production in the classic speech area (Broca's area) but not in its right-hemisphere homologue at the second evaluation. This increase in cortical flow may have been compensatory for cerebellar degeneration as speech intelligibility did not decline significantly during this period. Compensation was not complete, though, as syllable timing shifted in the direction of equal syllable duration, one of the characteristics of ataxic dysarthria. These results are consistent with previous functional imaging studies of ataxia demonstrating a pattern of brain activity that reflects both loss of function and relative compensation when clinical signs and symptoms are still mild. The combination of disease-relevant tasks, behavioral measurement, and functional imaging may provide insight into the early changes associated with neurodegenerative disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.