ArticleGastrointestinal endoscopy2010
Association of smoking and flat adenomas: results from an asymptomatic population screened with a high-definition colonoscope.
Article in Gastrointestinal endoscopy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Factors Associated With Shorter Colonoscopy Surveillance Intervals for Patients With Low-Risk Colorectal Adenomas and Effects on Outcome.Gastroenterology · 2017Trial
- Development and validation of a clinical score for predicting risk of adenoma at screening colonoscopy.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Trial
- Outcomes and Characteristics Across Age Groups of Patients with Positive MT-sDNA Stool Tests: Data from the New Hampshire Colonoscopy Registry.Digestive diseases and sciences · 2026Article
- Yield of Synchronous Adenomas and Serrated Polyps in Patients With Positive Stool Tests (mt-sDNA or FIT): Data From the New Hampshire Colonoscopy Registry.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Increased risk of metachronous large serrated polyps in individuals with 5- to 9-mm proximal hyperplastic polyps: data from the New Hampshire Colonoscopy Registry.Gastrointestinal endoscopy · 2020Article
- Young adults and metachronous neoplasia: risks for future advanced adenomas and large serrated polyps compared with older adults.Gastrointestinal endoscopy · 2020Article
- Risk factors for colorectal cancer significantly vary by anatomic site.BMJ open gastroenterology · 2019Article
- Exposure to Cigarette Smoke Contributes to the Risk of Developing a Colorectal Adenoma, Doesn't It? Are Repeated Exposures to Such Smoke Dangerous?Annals of coloproctology · 2016Article
- Do recent epidemiologic observations impact who and how we should screen for CRC?Digestive diseases and sciences · 2015Review
- Prevalence of colorectal adenomatous polyps in patients with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2015Article
- Plasma insulin, glucose, IGF-I, IGF-II, and IGFBP-3 and risk of recurrent colorectal adenomas.Journal of gastroenterology and hepatology research · 2013Article
- Smoking and the association of advanced colorectal neoplasia in an asymptomatic average risk population: analysis of exposure and anatomical location in men and women.Digestive diseases and sciences · 2011Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFlat adenomas represent a morphologically distinct class of polyps that may be difficult to detect, and little is known regarding risk factors for these lesions. Identification of risk factors for these lesions may aid in colorectal cancer (CRC) screening, because patients at risk for these lesions may require special imaging techniques. Smoking, an important risk factor for CRC, may be associated with molecular changes that increase the risk for flat adenomas.
objectiveThe aim of this study was to examine the association between smoking and flat adenomas.
designProspective cross-sectional study.
settingUniversity hospital endoscopy center. PATIENTS: We enrolled asymptomatic patients presenting for CRC screening.
interventionsWe screened patients with a high-definition (1080i signal) wide-angle (170 degrees field of view) Olympus 180-series colonoscope. We collected demographics, medication use, family history of CRC, diet history, and smoking history. MAIN OUTCOME MEASUREMENTS: Polyp morphology, assessed by using the Japanese Research Society Classification (JRSC).
resultsA total of 600 patients were enrolled. We observed that smoking was associated with having a flat adenoma of any size (adjusted odds ratio [OR], 2.53; 95% CI, 1.60-4.00), having only flat adenomas that were > or = 6 mm in diameter (adjusted OR, 3.84; 95% CI, 2.02-7.32), as well as flat advanced adenomas (adjusted OR, 2.81; 95% CI, 1.08-7.30). LIMITATIONS: The study design may not account for some confounding variables and provides no information regarding smoking status at the time of initiation of flat adenomas.
conclusionSmoking was associated with flat adenomas in our population. Our findings may explain the earlier onset of CRC in smokers as well as the advanced stage with which they present, with compared with nonsmokers. Smokers may require screening with high-definition colonoscopes to detect flat adenomas.
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