ArticleExperimental hematology2010
Amelioration of a mouse model of osteogenesis imperfecta with hematopoietic stem cell transplantation: microcomputed tomography studies.
Article in Experimental hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
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- Biomimetic Silk Fibroin Scaffolds Functionalized with Hydroxyapatite and Platelet Growth Factors for Bone Tissue Engineering.Biomimetics (Basel, Switzerland) · 2025Article
- Emerging Landscape of Osteogenesis Imperfecta Pathogenesis and Therapeutic Approaches.ACS pharmacology & translational science · 2024Review
- Enzyme-Cleaved Bone Marrow Transplantation Improves the Engraftment of Bone Marrow Mesenchymal Stem Cells.JBMR plus · 2023Article
- Teaching Surgical Model Development in Research by Using Situated Learning and Instructional Scaffolding.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Hematopoietic Stem Cells as a Novel Source of Dental Tissue Cells.Scientific reports · 2018Article
- Developments in rare bone diseases and mineral disorders.Therapeutic advances in chronic disease · 2018Review
- Early clinical applications for imaging at microscopic detail: microfocus computed tomography (micro-CT).The British journal of radiology · 2017Review
- Skeletal Dysplasias: Growing Therapy for Growing Bones.Frontiers in pharmacology · 2017Review
- Transplanted murine long-term repopulating hematopoietic cells can differentiate to osteoblasts in the marrow stem cell niche.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Further proof for an unpopular concept: a single cell from bone marrow can serve as a stem cell for both hematopoiesis and osteogenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Gender-dependence of bone structure and properties in adult osteogenesis imperfecta murine model.Annals of biomedical engineering · 2013Article
- Hematopoietic stem cells are pluripotent and not just "hematopoietic".Blood cells, molecules & diseases · 2013Review
- Stem cells for reprogramming: could hUMSCs be a better choice?Cytotechnology · 2013Article
- Allele dependent silencing of collagen type I using small interfering RNAs targeting 3'UTR Indels - a novel therapeutic approach in osteogenesis imperfecta.International journal of medical sciences · 2013Article
- Hematopoietic stem cells give rise to osteo-chondrogenic cells.Blood cells, molecules & diseases · 2013Article
- Wnt1 Accelerates an Ex Vivo Expansion of Human Cord Blood CD34(+)CD38(-) Cells.Stem cells international · 2013Article
- Hematopoietic stem cell development, niches, and signaling pathways.Bone marrow research · 2012Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that hematopoietic stem cells (HSCs) generate bone cells using bone marrow (BM) cell transplantation in a mouse model of osteogenesis imperfecta (OI). OI is a genetic disorder resulting from abnormal amount and/or structure of type I collagen and is characterized by osteopenia, fragile bones, and skeletal deformities. Homozygous OI murine mice (oim; B6C3Fe a/a-Col1a2(oim)/J) offer excellent recipients for transplantation of normal HSCs, because fast turnover of osteoprogenitors has been shown. MATERIALS AND
methodsWe transplanted BM mononuclear cells or 50 BM cells highly enriched for HSCs from transgenic enhanced green fluorescent protein mice into irradiated oim mice and analyzed changes in bone parameters using longitudinal microcomputed tomography.
resultsDramatic improvements were observed in three-dimensional microcomputed tomography images of these bones 3 to 6 months post-transplantation when the mice showed high levels of hematopoietic engraftment. Histomorphometric assessment of the bone parameters, such as trabecular structure and cortical width, supported observations from three-dimensional images. There was an increase in bone volume, trabecular number, and trabecular thickness with a concomitant decrease in trabecular spacing. Analysis of a nonengrafted mouse or a mouse that was transplanted with BM cells from oim mice showed continued deterioration in the bone parameters. The engrafted mice gained weight and became less prone to spontaneous fractures while the control mice worsened clinically and eventually developed kyphosis.
conclusionsThese findings strongly support the concept that HSCs generate bone cells. Furthermore, they are consistent with observations from clinical transplantation studies and suggest therapeutic potentials of HSCs in OI.
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