ArticleBiochemical and biophysical research communications2010
Deficiency of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 accelerates atherogenesis in apolipoprotein E-deficient mice.
Article in Biochemical and biophysical research communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Poldip2 knockdown inhibits vascular smooth muscle proliferation and neointima formation by regulating the expression of PCNA and p21.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Anti-Angiogenic miR-222, miR-195, and miR-21a Plasma Levels in T1DM Are Improved by Metformin Therapy, Thus Elucidating Its Cardioprotective Effect: The MERIT Study.International journal of molecular sciences · 2018Article
- Galectin-3 inhibition ameliorates hypoxia-induced pulmonary artery hypertension.Molecular medicine reports · 2017Article
- The COP9 signalosome and vascular function: intriguing possibilities?American journal of cardiovascular disease · 2015Review
- Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling.BioMed research international · 2015Review
- A selective microRNA-based strategy inhibits restenosis while preserving endothelial function.The Journal of clinical investigation · 2014Article
- A form of the metabolic syndrome associated with mutations in DYRK1B.The New England journal of medicine · 2014Article
- Baicalin inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via the AKT/HIF-1α/p27-associated pathway.International journal of molecular sciences · 2014Article
- Elevation of miR-221 and -222 in the internal mammary arteries of diabetic subjects and normalization with metformin.Molecular and cellular endocrinology · 2013Article
- Dysregulation of the Mammalian Target of Rapamycin and p27Kip1 Promotes Intimal Hyperplasia in Diabetes Mellitus.Pharmaceuticals (Basel, Switzerland) · 2013Article
- Tanshinone IIA inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via Akt/Skp2/p27-associated pathway.PloS one · 2013Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Cyclin-dependent kinase inhibitors, p21(Cip1) and p27(Kip1), are upregulated during vascular cell proliferation and negatively regulate growth of vascular cells. We hypothesized that absence of either p21(Cip1) or p27(Kip1) in apolipoprotein E (apoE)-deficiency may increase atherosclerotic plaque formation. Compared to apoE(-/-) aortae, both apoE(-/-)/p21(-/-) and apoE(-/-)/p27(-/-) aortae exhibited significantly more atherosclerotic plaque following a high-cholesterol regimen. This increase was particularly observed in the abdominal aortic regions. Deficiency of p27(Kip1) accelerated plaque formation significantly more than p21(-/-) in apoE(-/-) mice. This increased plaque formation was in parallel with increased intima/media area ratios. Deficiency of p21(Cip1) and p27(Kip1) accelerates atherogenesis in apoE(-/-) mice. These findings have significant implications for our understanding of the molecular basis of atherosclerosis associated with excessive proliferation of vascular cells.
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