ArticleMicrobes and infection2010
The acute phase reactant response to respiratory infection with Chlamydia pneumoniae: implications for the pathogenesis of atherosclerosis.
Article in Microbes and infection, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis.Mediators of inflammation · 2015Pooled it
- High frequency of Chlamydia pneumoniae and risk factors in children with acute respiratory infection.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Iron Homeostasis in Tissues Is Affected during PersistentBioMed research international · 2017Article
- Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota.Atherosclerosis · 2015Review
- Infection and Atherosclerosis Development.Archives of medical research · 2015Review
- Infection with Chlamydia pneumoniae as a cause of coronary heart disease: the hypothesis is still untested.Pathogens and disease · 2015Review
- Chlamydia pneumoniae Clinical Isolate from Gingival Crevicular Fluid: A Potential Atherogenic Strain.Frontiers in cellular and infection microbiology · 2015Article
- Infectious burden and atherosclerosis: A clinical issue.World journal of clinical cases · 2014Review
- Significant roles played by IL-10 in Chlamydia infections.Inflammation · 2014Review
- Correlation of atherogenesis with an infection of Candida albicans.International journal of clinical and experimental medicine · 2014Article
- Inflammation and atherosclerosis: direct versus indirect mechanisms.Current opinion in pharmacology · 2013Review
- Is there any relationship between Chlamydophila pneumoniae and coronary atherosclerosis among Iranians?Nigerian medical journal : journal of the Nigeria Medical Association · 2013Article
- Modulation of paraoxonases during infectious diseases and its potential impact on atherosclerosis.Lipids in health and disease · 2012Review
- Effect of filarial infection on serum inflammatory and atherogenic biomarkers in coronary artery disease (CURES-121).The American journal of tropical medicine and hygiene · 2012Article
- Accelerated atherosclerosis in patients with SLE--mechanisms and management.Nature reviews. Rheumatology · 2012Review
- Systemic lupus erythematosus and cardiovascular disease: prediction and potential for therapeutic intervention.Expert review of clinical immunology · 2011Review
- Hydrodynamic regulation of monocyte inflammatory response to an intracellular pathogen.PloS one · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The acute phase response to Chlamydia pneumoniae infection was analyzed over a 72 h period post-infection in C57BL/6J mice. A single intra-nasal inoculation stimulated statistically significant increases in the plasma levels of IL-2, IL-5, IL-6, IL-10, IL-12, GM-CSF, IFN-gamma, and serum amyloid A but not TNF-alpha, IL-1beta, IL-4 and serum amyloid P. There was also a decrease in the activity of the HDL protective enzyme paraoxonase as well as a reduced ability of HDL to prevent oxidation of palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine by hydroperoxyoctadecadienoic acid at 48 and 72 h post-infection. To determine whether the C. pneumoniae induced acute phase response had any effect on atherosclerotic plaque stability, we measured the frequency of intra-plaque hemorrhage as a marker of plaque disruption in the innominate arteries of apolipoprotein E deficient mice at 29-30 weeks and 1.5-2.0 years of age. There was an increased frequency of intra-plaque hemorrhage only in the older mice infected with the live organism (8/14) as compared to mice treated with killed C. pneumoniae (2/11) or sham inoculated with PBS (2/12). These results suggest that acute phase reactant proteins produced in response to pulmonary infection with C. pneumoniae may contribute to the progression and destabilization of atherosclerotic lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.