ArticleRespiratory research2010
Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable?
Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Analysis of Olfactive Prints from Artificial Lung Cancer Volatolome with Nanocomposite-Based vQRS Arrays for Healthcare.Biosensors · 2025Article
- The Impact of COVID-19 on the Oral Bacterial Flora in Patients Wearing Complete Dentures and on the Level of Exhaled Nitric Oxide as a Marker of Inflammation.Journal of clinical medicine · 2023Article
- An Evidence-Based Review of Application Devices for Nitric Oxide Concentration Determination from Exhaled Air in the Diagnosis of Inflammation and Treatment Monitoring.Molecules (Basel, Switzerland) · 2022Review
- Fractional exhaled nitric oxide-measuring devices: technology update.Medical devices (Auckland, N.Z.) · 2016Review
- Reproducibility of exhaled nitric oxide measurements in overweight and obese adults.BMC research notes · 2014Article
- Validation of a portable nitric oxide analyzer for screening in primary ciliary dyskinesias.BMC pulmonary medicine · 2014Article
- Decreased exhaled nitric oxide levels in patients with mitochondrial disorders.The open respiratory medicine journal · 2013Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExhaled nitric oxide is a non-invasive marker of airway inflammation and a portable analyser, the NIOX MINO (Aerocrine AB, Solna, Sweden), is now available. This study aimed to assess the reproducibility of the NIOX MINO measurements across age, sex and lung function for both absolute and categorical exhaled nitric oxide values in two distinct groups of children and teenagers.
methodsPaired exhaled nitric oxide readings were obtained from 494 teenagers, aged 16-18 years, enrolled in an unselected birth cohort and 65 young people, aged 6-17 years, with asthma enrolled in an interventional asthma management study.
resultsThe birth cohort participants showed a high degree of variability between first and second exhaled nitric oxide readings (mean intra-participant difference 1.37 ppb, 95% limits of agreement -7.61 to 10.34 ppb), although there was very close agreement when values were categorised as low, normal, intermediate or high (kappa = 0.907, p < 0.001). Similar findings were seen in subgroup analyses by sex, lung function and asthma status. Similar findings were seen in the interventional study participants.
conclusionsThe reproducibility of exhaled nitric oxide is poor for absolute values but acceptable when values are categorised as low, normal, intermediate or high in children and teenagers. One measurement is therefore sufficient when using categorical exhaled nitric oxide values to direct asthma management but a mean of at least two measurements is required for absolute values.
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