Evidence map›Paper›PMID 20415982›Full record

ReviewRespirology (Carlton, Vic.)2010

The immunology of tuberculosis: from bench to bedside.

Keertan Dheda, Stephan K Schwander, Bingdong Zhu, Richard N van Zyl-Smit, Ying Zhang

Abstract readReview
In one paragraph

Review in Respirology (Carlton, Vic.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
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  7. Article
  8. Article
  9. IFN-γ-Driven macrophage responses in the immunity toFrontiers in cellular and infection microbiology · 2025
    Review
  10. Article
  11. Article
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  13. Article
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  15. [Potential use of liposomes in tuberculosis treatment].Revista medica del Instituto Mexicano del Seguro Social · 2023
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Keertan DhedaDivision of Pulmonology and Clinical Immunology & UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa. keertan.dheda@uct.ac.za
Stephan K Schwander
Bingdong Zhu
Richard N van Zyl-Smit
Ying Zhang

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
MODE OF ACTION OF PYRAZINAMIDE IN TUBERCLE BACILLUSR01AI044063 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ZHANG, YING · 1999 to 2009
$2.6M
Diesel Exhaust Particle Effects on Human Immunity to Mycobacterium tuberculosisR21ES016928 · NIEHS · UNIV OF MED/DENT NJ-SCH OF PUBLIC HEALTH · PI SCHWANDER, STEPHAN K · 2008 to 2010
$439k
CIHRFIC NIH HHS R24 TW007988FIC NIH HHS R24TW007988NIAID NIH HHS R01 AI044063NIAID NIH HHS R01AI44063NIEHS NIH HHS R21 ES016928NIEHS NIH HHS R21 R21ES016928-02
6 · The paper itself

Abstract

Tuberculosis (TB) is an international public health priority and kills almost two million people annually. TB is out of control in Africa due to increasing poverty and HIV coinfection, and drug-resistant TB threatens to destabilize TB control efforts in several regions of the world. Existing diagnostic tools and therapeutic interventions for TB are suboptimal. Thus, new vaccines, immunotherapeutic interventions and diagnostic tools are urgently required to facilitate TB control efforts. An improved understanding of the immunopathogenesis of TB can facilitate the identification of correlates of immune protection, the design of effective vaccines, the rational selection of immunotherapeutic agents, the evaluation of new drug candidates, and drive the development of new immunodiagnostic tools. Here we review the immunology of TB with a focus on aspects that are clinically and therapeutically relevant. An immunologically orientated approach to tackling TB can only succeed with concurrent efforts to alleviate poverty and reduce the global burden of HIV.

Indexed as

AnimalsDrug Resistance, BacterialHumansImmunotherapyLatent TuberculosisLife Cycle StagesMycobacterium tuberculosisTuberculosisTuberculosis VaccinesTuberculosis Vaccines

Identifiers

PMID20415982
PMCPMC5463744

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.