ReviewExpert opinion on emerging drugs2010
The future is today: emerging drugs for the treatment of erectile dysfunction.
Review in Expert opinion on emerging drugs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Neural correlates of antidepressant-related sexual dysfunction: a placebo-controlled fMRI study on healthy males under subchronic paroxetine and bupropion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Factors Influencing Continued Usage of Intracavernosal injections for Erectile Dysfunction: A Retrospective Analysis.The world journal of men's health · 2025Article
- Inflammatory biomarkers may predict response to phosphodiesterase type 5 inhibitor treatment in patients with erectile dysfunction.Investigative and clinical urology · 2023Article
- The retinal neurovascular coupling is impaired in men with vasculogenic erectile dysfunction.Scientific reports · 2023Article
- Impact of COVID-19 on male urogenital health: Success of vaccines.Drug discovery today · 2022Review
- Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons.Molecular brain · 2021Article
- Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions.Investigative ophthalmology & visual science · 2021Article
- An Update on the Relationship of SARS-CoV-2 and Male Reproduction.Frontiers in endocrinology · 2021Review
- A novel ROCK inhibitor: off-target effects of metformin.Turkish journal of biology = Turk biyoloji dergisi · 2021Article
- Perspectives on ROCK2 as a Therapeutic Target for Alzheimer's Disease.Frontiers in cellular neuroscience · 2021Article
- A Critical Analysis of Methodology Pitfalls in Duplex Doppler Ultrasound in the Evaluation of Patients With Erectile Dysfunction: Technical and Interpretation Deficiencies.The journal of sexual medicine · 2020Review
- Extracorporeal Shock Waves Therapy Delivered by Aries Improves Erectile Dysfunction in Spontaneously Hypertensive Rats Through Penile Tissue Remodeling and Neovascularization.Sexual medicine · 2019Article
- Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors.Behavioural brain research · 2019Article
- Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity.Brain structure & function · 2018Article
- PDE5 inhibitors - pharmacology and clinical applications 20 years after sildenafil discovery.British journal of pharmacology · 2018Review
- Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury.International journal of molecular sciences · 2017Review
- Erectile dysfunction.Nature reviews. Disease primers · 2016Review
- Herb drug interaction: effect of Manix® on pharmacokinetic parameters of pefloxacin in rat model.Asian Pacific journal of tropical biomedicine · 2014Article
- Erectile dysfunction in the elderly: an old widespread issue with novel treatment perspectives.International journal of endocrinology · 2014Review
- The potent relaxant effect of resveratrol in rat corpus cavernosum and its underlying mechanisms.International journal of impotence research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
importance of the fieldErectile dysfunction (ED) is the most common male sexual dysfunction presented for treatment affecting between 10 and 20% of men. PDE type 5 inhibitors (PDE5I) now account for the largest segment of the ED market. While these drugs are highly efficacious for many men, a relatively large subset of ED patients who do not respond to PDE5I is increasingly recognized. AREAS COVERED IN THIS REVIEW: In this review, we discuss clinical and preclinical evidence supporting various emerging compounds that regulate penile erection both centrally (clavulanic acid, dopamine and melanocortin receptor agonists) and peripherally (novel PDE5I, soluble and particulate guanylil cyclase activators, rho-kinase inhibitors and maxi-K channel openers). WHAT THE READER WILL GAIN: The reader will gain a broad understanding of erectile (patho-)physiology and gain insights in the mechanisms of action, efficacy and adverse events of various compounds under development for the treatment of ED. TAKE HOME MESSAGE: We expect emerging drugs to allow treatment protocols tailored to the specific needs of each individual patient, taking into consideration the efficacy of erectile performance enhancement and the potential for adverse events. This tailored approach may include combination of various emerging drugs to enhance efficacy in difficult-to-treat patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.