Trial reportThe Journal of infectious diseases2010
Increased risk of HIV acquisition among Kenyan men with human papillomavirus infection.
Trial report in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01387412 (The Role of Genital Warts in HIV Acquisition Among MSM in Peru"), which is not on this map. Cited by 46 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Genital Warts in HIV Acquisition Among MSM in Peru"
Who cites it
46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Evidence of synergistic relationships between HIV and Human Papillomavirus (HPV): systematic reviews and meta-analyses of longitudinal studies of HPV acquisition and clearance by HIV status, and of HIV acquisition by HPV status.Journal of the International AIDS Society · 2018Pooled it
- Association of genital human papillomavirus infection with HIV acquisition: a systematic review and meta-analysis.Sexually transmitted infections · 2013Pooled it
- Human papillomavirus infection and increased risk of HIV acquisition. A systematic review and meta-analysis.AIDS (London, England) · 2012Pooled it
- Genital ulcer disease treatment for reducing sexual acquisition of HIV.The Cochrane database of systematic reviews · 2012Pooled it
- Prevalence of sexually transmitted co-infections in people living with HIV/AIDS: systematic review with implications for using HIV treatments for prevention.Sexually transmitted infections · 2011Pooled it
- High HIV, HPV, and STI prevalence among young Western Cape, South African women: EVRI HIV prevention preparedness trial.Journal of acquired immune deficiency syndromes (1999) · 2015Trial
- Risk of HIV acquisition among circumcised and uncircumcised young men with penile human papillomavirus infection.AIDS (London, England) · 2014Trial
- Article
- Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk.Frontiers in immunology · 2023Review
- Incidence and clearance of penile human papillomavirus infection among circumcised Kenyan men.International journal of STD & AIDS · 2020Article
- HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection.Frontiers in immunology · 2020Article
- Depletion and activation of mucosal CD4 T cells in HIV infected women with HPV-associated lesions of the cervix uteri.PloS one · 2020Article
- Condylomata Acuminata (Anogenital Warts) Contain Accumulations of HIV-1 Target Cells That May Provide Portals for HIV Transmission.The Journal of infectious diseases · 2019Article
- Prevalence of oncogenic human papillomavirus genotypes in patients diagnosed with anogenital malignancies in Botswana.BMC infectious diseases · 2017Article
- Prevalence of anogenital HPV infection, related disease and risk factors among HIV-infected men in inner-city Johannesburg, South Africa: baseline findings from a cohort study.BMC public health · 2017Article
- Anogenital Human Papillomavirus Infection and HIV Infection Outcomes Among Peruvian Transgender Women: Results from a Cohort Study.Transgender health · 2016Article
- Human papillomavirus prevalence in South African women and men according to age and human immunodeficiency virus status.BMC infectious diseases · 2015Article
- Serological test results of sexually transmitted diseases in patients with condyloma acuminata.Postepy dermatologii i alergologii · 2015Article
- Prevalence, Incidence, and Clearance of Anogenital Warts in Kenyan Men Reporting High-Risk Sexual Behavior, Including Men Who Have Sex With Men.Open forum infectious diseases · 2015Article
- HPV Carcinomas in Immunocompromised Patients.Journal of clinical medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 5 countries.
Funding
Abstract
backgroundFew data on the effect of human papillomavirus (HPV) infection on human immunodeficiency virus (HIV) acquisition are available.
methodsHIV-seronegative, sexually active, 18-24-year-old Kenyan men participating in a randomized trial of male circumcision provided exfoliated penile cells from 2 anatomical sites (glans/coronal sulcus and shaft) at baseline. The GP5+/6+ polymerase chain reaction assay ascertained a wide range of HPV DNA types at the baseline visit. The risk of HIV infection was estimated using Kaplan-Meier methods and hazard ratios from proportional hazards models.
resultsOf 2168 uncircumcised men with baseline HPV data, 1089 (50%) were positive for HPV DNA. The cumulative incidence of HIV infection by 42 months was 5.8% (95% confidence interval [CI], 3.6%-7.9%) among men with HPV-positive glans/coronal sulcus specimens, versus 3.7% [95% CI, 1.8%-5.6%] among men with HPV-negative glans/coronal sulcus specimens (P = .01). Controlling for subsequent circumcision status, baseline herpes simplex virus type 2 serostatus, and sexual and sociodemographic risk factors, the hazard ratio for HIV infection among men with HPV-positive glans/coronal sulcus specimens was 1.8 (95% CI, 1.1-2.9), compared with men with HPV-negative glans/coronal sulcus specimens.
conclusionThe results suggest an independent increased risk of HIV seroconversion among HPV-positive men. If this finding is confirmed in other studies, HPV prevention could be another tool for HIV prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.