ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2010
Late presentation for human immunodeficiency virus care in the United States and Canada.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
117 citing papers in PubMed, 2 syntheses or guidelines pooled it, 202 citations in OpenAlex.
- Late presentation of HIV positive adults and its predictors to HIV/AIDS care in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- A systematic review of HIV/AIDS survival and delayed diagnosis among Hispanics in the United States.Journal of immigrant and minority health · 2012Pooled it
- Ancillary service needs among persons new to HIV care and the relationship between needs and late presentation to care.AIDS care · 2019Trial
- The evolving HIV epidemic in Ontario, Canada: A retrospective analysis of new HIV diagnoses to identify subpopulations with persistent risk of HIV transmission.Canadian journal of public health = Revue canadienne de sante publique · 2025Article
- A Closer Look at the Perceived Factors Contributing To Late HIV Diagnoses: A Qualitative Study among People with HIV.AIDS and behavior · 2025Article
- Atherosclerosis and Cardiovascular Complications in People Living with HIV: A Focused Review.Infectious disease reports · 2024Review
- Clonal hematopoiesis in people with advanced HIV and associated inflammatory syndromes.JCI insight · 2024Article
- Association of demographics, HCV co-infection, HIV-1 subtypes and genetic clustering with late HIV diagnosis: a retrospective analysis from the Japanese Drug Resistance HIV-1 Surveillance Network.Journal of the International AIDS Society · 2023Article
- Predicting Risk of Multidrug-Resistant Enterobacterales Infections Among People With HIV.Open forum infectious diseases · 2022Article
- Longitudinal analysis of HIV outcomes for persons living with HIV in non-urban areas in southern Alberta, Canada.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2022Article
- HIV-Related Stigma Reduction in the Era of Undetectable Equals Untransmittable: The South Korean Perspective.Infection & chemotherapy · 2021Review
- Different Trends of Distinct Time Points of AIDS Events Following HIV Diagnosis in Various At-risk Populations: A Retrospective Nationwide Cohort Study in Taiwan.Infectious diseases and therapy · 2021Article
- The shifting picture of HIV treatment, comorbidity and substance use among US MSM living with HIV.HIV medicine · 2021Article
- Racial, ethnic, and gender disparities in hospitalizations among persons with HIV in the United States and Canada, 2005-2015.AIDS (London, England) · 2021Article
- Late initiation of antiretroviral therapy: inequalities by educational level despite universal access to care and treatment.BMC public health · 2021Article
- The effectiveness of rituximab and HIV on the survival of Ontario patients with diffuse large B-cell lymphoma.Cancer medicine · 2020Article
- Different transmission routes and the risk of advanced HIV disease: A systematic review and network meta-analysis of observational studies.EClinicalMedicine · 2019Article
- Management of Advanced HIV Disease.Infectious disease clinics of North America · 2019Review
- Viral suppression and HIV transmission behaviors among hospitalized patients living with HIV.International journal of STD & AIDS · 2019Article
- How to Evolve the Response to the Global HIV Epidemic With New Metrics and Targets Based on Pre-Treatment CD4 Counts.Current HIV/AIDS reports · 2019Review
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 16 institutions in 2 countries.
Funding
Abstract
BACKGROUND. Initiatives to improve early detection and access to human immunodeficiency virus (HIV) services have increased over time. We assessed the immune status of patients at initial presentation for HIV care from 1997 to 2007 in 13 US and Canadian clinical cohorts. METHODS. We analyzed data from 44,491 HIV-infected patients enrolled in the North American-AIDS Cohort Collaboration on Research and Design. We identified first presentation for HIV care as the time of first CD4(+) T lymphocyte (CD4) count and excluded patients who prior to this date had HIV RNA measurements, evidence of antiretroviral exposure, or a history of AIDS-defining illness. Trends in mean CD4 count (measured as cells/mm(3)) and 95% confidence intervals were determined using linear regression adjusted for age, sex, race/ethnicity, HIV transmission risk, and cohort. RESULTS. Median age at first presentation for HIV care increased over time (range, 40-43 years; P < .01), whereas the percentage of patients with injection drug use HIV transmission risk decreased (from 26% to 14%; P < .01) and heterosexual transmission risk increased (from 16% to 23%; P < .01). Median CD4 count at presentation increased from 256 cells/mm(3) (interquartile range, 96-455 cells/mm(3)) to 317 cells/mm(3) (interquartile range, 135-517 cells/mm(3)) from 1997 to 2007 (P < .01). The percentage of patients with a CD4 count > or = 350 cells/mm(3) at first presentation also increased from 1997 to 2007 (from 38% to 46%; P < .01). The estimated adjusted mean CD4 count increased at a rate of 6 cells/mm(3) per year (95% confidence interval, 5-7 cells/mm(3) per year). CONCLUSION. CD4 count at first presentation for HIV care has increased annually over the past 11 years but has remained <350 cells/mm(3), which suggests the urgent need for earlier HIV diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.