ArticleThe Journal of infectious diseases2010
Interactions between human phagocytes and Candida albicans biofilms alone and in combination with antifungal agents.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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Who cites it
55 citing papers in PubMed, 102 citations in OpenAlex.
- The hypoxic microenvironment ofFrontiers in immunology · 2025Article
- Perspectives on the Use of Echinocandins in the Neonatal Intensive Care Unit.Antibiotics (Basel, Switzerland) · 2024Review
- Molecular Determinants Involved in Candida albicans Biofilm Formation and Regulation.Molecular biotechnology · 2024Review
- Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis.PLoS pathogens · 2024Article
- Complexation of fungal extracellular nucleic acids by host LL-37 peptide shapes neutrophil response toFrontiers in immunology · 2024Article
- Osteoarticular Mycoses.Clinical microbiology reviews · 2022Review
- Biofilm Formation by Chromoblastomycosis FungiJournal of fungi (Basel, Switzerland) · 2022Article
- Antifungal and Anti-Virulent Activity ofMolecules (Basel, Switzerland) · 2022Article
- Fungi-A Component of the Oral Microbiome Involved in Periodontal Diseases.Advances in experimental medicine and biology · 2022Article
- Promising Anti-Biofilm Agents and Phagocytes Enhancers for the Treatment ofFrontiers in cellular and infection microbiology · 2022Article
- Reverse effects ofFrontiers in cellular and infection microbiology · 2022Article
- Review
- Intestinal Infection ofFrontiers in microbiology · 2021Review
- Candidemia: Evolution of Drug Resistance and Novel Therapeutic Approaches.Infection and drug resistance · 2021Review
- Automated quantification of Candida albicans biofilm-related phenotypes reveals additive contributions to biofilm production.NPJ biofilms and microbiomes · 2020Article
- Toward Harmonization of Voriconazole CLSI and EUCAST Breakpoints for Candida albicans Using a ValidatedAntimicrobial agents and chemotherapy · 2020Article
- Contributions of the Biofilm Matrix toJournal of fungi (Basel, Switzerland) · 2020Review
- How Biofilm Growth AffectsFrontiers in microbiology · 2020Review
- Neutrophils From Patients With Invasive Candidiasis Are Inhibited byFrontiers in immunology · 2020Article
- Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBiofilm formation is an important component of vascular catheter infections caused by Candida albicans. Little is known about the interactions between human phagocytes, antifungal agents, and Candida biofilms.
methodsThe interactions between C. albicans biofilms and human phagocytes alone and in combination with anidulafungin or voriconazole were investigated and compared with their corresponding planktonic counterparts by means of an in vitro biofilm model with clinical intravascular and green fluorescent protein (GFP)-expressing strains. Phagocyte-mediated and antifungal agent-mediated damages were determined by 2,3-bis[ 2- methoxy-4-nitro-5-sulfophenyl]2H-tetrazolium-5-carboxanilide assay, and structural effects were visualized by confocal microscopy. Oxidative burst was evaluated by flow cytometric measurement of dihydrorhodamine 123 oxidation, and cytokine release was measured by enzyme-linked immunosorbent assay.
resultsPhagocytes alone and in combination with antifungal agents induced less damage against biofilms compared with planktonic cells. However, additive effects occurred between phagocytes and anidulafungin against Candida biofilms. Confocal microscopy demonstrated the absence of phagocytosis within biofilms but marked destruction caused by anidulafungin and phagocytes. Anidulafungin but not voriconazole elicited tumor necrosis factor alpha release from phagocytes compared with that from untreated biofilms.
conclusionsC. albicans within biofilms are more resistant to phagocytic host defenses but are susceptible to additive effects between phagocytes and an echinocandin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.