ArticleThe journal of physical chemistry. B2010
Raman studies of solution polyglycine conformations.
Article in The journal of physical chemistry. B, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo-Electron Tomography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Orientation affects hydrogen bonding cooperativity in polyproline II helical bundles.Communications chemistry · 2025Article
- Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selection.Frontiers in immunology · 2025Article
- Hydrogen bonding patterns and cooperativity in polyproline II helical bundles.Communications chemistry · 2024Article
- Free fatty acid receptors beyond fatty acids: A computational journey to explore peptides as possible binders of GPR120.Current research in food science · 2024Article
- Structural Basis of PE_PGRS Polymorphism, a Tool for Functional Modulation.Biomolecules · 2023Article
- Article
- Polypeptide Chain Growth Mechanisms and Secondary Structure Formation in Glycine Gas-Phase Deposition on Silica Surfaces.The journal of physical chemistry. B · 2023Article
- Emergence of Order in Origin-of-Life Scenarios on Mineral Surfaces: Polyglycine Chains on Silica.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Two-Dimensional Triblock Peptide Assemblies for the Stabilization of Pickering Emulsions with pH Responsiveness.ACS applied materials & interfaces · 2022Article
- Molecular Insights into the Binding of Linear Polyethylenimines and Single-Stranded DNA Using Raman Spectroscopy: A Quantitative Approach.The journal of physical chemistry. B · 2022Article
- Poly-Gly Region Regulates the Accessibility of Metal Binding Sites in Snake Venom Peptides.Inorganic chemistry · 2022Article
- A comparison of three DFT exchange-correlation functionals and two basis sets for the prediction of the conformation distribution of hydrated polyglycine.The Journal of chemical physics · 2021Article
- Kirkwood-Buff-Derived Force Field for Peptides and Proteins: Applications of KBFF20.Journal of chemical theory and computation · 2021Article
- PE_PGRS33, an Important Virulence Factor ofCells · 2021Review
- Glycine in Water Favors the Polyproline II State.Biomolecules · 2020Article
- Molecular basis for the folding of β-helical autotransporter passenger domains.Nature communications · 2018Article
- Force field-dependent solution properties of glycine oligomers.Journal of computational chemistry · 2015Article
- Quantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturation.Journal of the American Chemical Society · 2015Article
- Helix stability of oligoglycine, oligoalanine, and oligo-β-alanine dodecamers reflected by hydrogen-bond persistence.Proteins · 2014Article
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Authors and funding
2 authors.
Funding
Abstract
Polyglycine (polygly) is an important model system for understanding the structural preferences of unfolded polypeptides in solution. We utilized UV resonance and visible Raman spectroscopy to investigate the conformational preferences of polygly peptides of different lengths in water containing LiCl and LiClO(4). Lithium salts increase the solubility of polygly. Our study indicates that in solution the conformational ensemble of polygly, as well as central peptide bonds of gly(5) and gly(6), are dominated by the 3(1) extended helix, also known as the polyglycine II conformation (PGII). This preference of the polygly backbone for the PGII conformation in solution is likely a result of favorable interactions between carbonyl dipoles in these extended helices. We found that high concentrations of Li(+) stabilize the PGII conformation in solution, most likely by polarizing the peptide bond carbonyls that makes PGII-stabilizing carbonyl-carbonyl electrostatic interactions more favorable. This ability of Li(+) to stabilize 3(1)-helix conformations in solution gives use to the denaturing ability of lithium salts.
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