ArticleJournal of agricultural and food chemistry2010
Glycoprotein expression in human milk during lactation.
Article in Journal of agricultural and food chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01817127 (Functional Deconstruction of Human Milk Oligosaccharides and Lipids), which is not on this map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Functional Deconstruction of Human Milk Oligosaccharides and Lipids
Who cites it
36 citing papers in PubMed.
- An exploratory analysis of the associations of human milk oligosaccharides and N-/O-glycans with infectious and allergic outcomes in the first year of life: the Japanese Human Milk Study Cohort.European journal of nutrition · 2026Article
- Comprehensive analysis of species-specific differences in fatty acid composition and proteome of milk fat globules in human and animals.Food chemistry: X · 2025Article
- Characterization of recombinant human lactoferrin expressed inThe Analyst · 2024Article
- Changes in glycosylated proteins in colostrum and mature milk and their implication.Frontiers in nutrition · 2023Article
- Analysis of Minor Proteins Present in Breast Milk by Using WGA Lectin.Children (Basel, Switzerland) · 2022Article
- Monitoring Human Milk β-Casein Phosphorylation andInternational journal of molecular sciences · 2021Article
- Article
- The Intake of a Cafeteria Diet in Nursing Rats Alters the Breast Milk Concentration of Proteins Important for the Development of Offspring.Nutrients · 2020Article
- Serum Protein N-Glycans in Colostrum and Mature Milk of Chinese Mothers.Journal of agricultural and food chemistry · 2020Article
- The Impact of Dietary Fucosylated Oligosaccharides and Glycoproteins of Human Milk on Infant Well-Being.Nutrients · 2020Review
- Interactions of Whey Proteins with Metal Ions.International journal of molecular sciences · 2020Review
- Article
- The Functional Power of the Human Milk Proteome.Nutrients · 2019Review
- Human Milk Proteins and Their Glycosylation Exhibit Quantitative Dynamic Variations during Lactation.The Journal of nutrition · 2019Article
- The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human.Microorganisms · 2018Review
- Milk Glycans and Their Interaction with the Infant-Gut Microbiota.Annual review of food science and technology · 2018Review
- Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development.Frontiers in pediatrics · 2018Review
- Quantitation of human milk proteins and their glycoforms using multiple reaction monitoring (MRM).Analytical and bioanalytical chemistry · 2017Article
- Potential of breastmilk analysis to inform early events in breast carcinogenesis: rationale and considerations.Breast cancer research and treatment · 2016Review
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
While milk proteins have been studied for decades, strikingly little effort has been applied to determining how the post-translational modifications (PTMs) of these proteins may change during the course of lactation. PTMs, particularly glycosylation, can greatly influence protein structure, function, and stability and can particularly influence the gut where their degradation products are potentially bioactive. In this work, previously undiscovered temporal variations in both expression and glycosylation of the glycoproteome of human milk are observed. Lactoferrin, one of the most abundant glycoproteins in human milk, is shown to be dynamically glycosylated during the first 10 days of lactation. Variations in expression or glycosylation levels are also demonstrated for several other abundant whey proteins, including tenascin, bile salt-stimulated lipase, xanthine dehydrogenase, and mannose receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.