Trial reportJournal of pharmacokinetics and pharmacodynamics2010
A two-compartment effect site model describes the bispectral index after different rates of propofol infusion.
Trial report in Journal of pharmacokinetics and pharmacodynamics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- The Drug Titration Paradox: Correlation of More Drug With Less Effect in Clinical Data.Clinical pharmacology and therapeutics · 2021Trial
- Propofol Breath Monitoring as a Potential Tool to Improve the Prediction of Intraoperative Plasma Concentrations.Clinical pharmacokinetics · 2016Trial
- Population pharmacokinetics and pharmacodynamics of propofol in morbidly obese patients.Clinical pharmacokinetics · 2011Trial
- A Deep Learning Framework for Anesthesia Depth Prediction from Drug Infusion History.Sensors (Basel, Switzerland) · 2023Article
- The influence of cardiac output on propofol and fentanyl pharmacokinetics and pharmacodynamics in patients undergoing abdominal aortic surgery.Journal of pharmacokinetics and pharmacodynamics · 2020Observational
- Article
- Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers.Anesthesiology · 2018Article
- Pharmacokinetics and pharmacodynamics of dexmedetomidine-induced vasoconstriction in healthy volunteers.British journal of clinical pharmacology · 2018Article
- Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents.Paediatric anaesthesia · 2015Article
- Review
- Population pharmacokinetic and pharmacodynamic model of propofol externally validated in children.Journal of pharmacokinetics and pharmacodynamics · 2015Article
- Pharmacokinetics and pharmacodynamics of propofol in cancer patients undergoing major lung surgery.Journal of pharmacokinetics and pharmacodynamics · 2015Article
- Automation of anaesthesia: a review on multivariable control.Journal of clinical monitoring and computing · 2015Review
- Pharmacokinetic-pharmacodynamic modelling in anaesthesia.British journal of clinical pharmacology · 2015Review
- Insights from neuroenergetics into the interpretation of functional neuroimaging: an alternative empirical model for studying the brain's support of behavior.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different estimates of the rate constant for the effect site distribution (k(e0)) of propofol, depending on the rate and duration of administration, have been reported. This analysis aimed at finding a more general pharmacodynamic model that could be used when the rate of administration is changed during the treatment. In a cross-over study, 21 healthy volunteers were randomised to receive a 1 min infusion of 2 mg/kg of propofol at one occasion, and a 1 min infusion of 2 mg/kg of propofol immediately followed by a 29 min infusion of 12 mg kg(-1) h(-1) of propofol at another occasion. Arterial plasma concentrations of propofol were collected up to 4 h after dosing, and BIS was collected before start of infusion and until the subjects were fully awake. The population pharmacokinetic-pharmacodynamic analysis was performed using NONMEM VI. A four-compartment PK model with time-dependent elimination and distribution described the arterial propofol concentrations, and was used as input to the pharmacodynamic model. A standard effect compartment model could not accurately describe the delay in the effects of propofol for both regimens, whereas a two-compartment effect site model significantly improved the predictions. The two-compartment effect site model included a central and a peripheral effect site compartment, possibly representing a distribution within the brain, where the decrease in BIS was linked to the central effect site compartment concentrations through a sigmoidal E(max) model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.