Trial reportInternational orthopaedics2011
Autologous bone grafting on steroids: preliminary clinical results. A novel treatment for nonunions and segmental bone defects.
Trial report in International orthopaedics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Reamer-irrigator-aspirator indications and clinical results: a systematic review.International orthopaedics · 2011Pooled it
- Article
- Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions-Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors.Bioengineering (Basel, Switzerland) · 2023Review
- 3D geometry of femoral reaming for bone graft harvesting.Scientific reports · 2021Article
- Autologous cell-based therapy for treatment of large bone defects: from bench to bedside.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Review
- Article
- Interaction between living bone particles and rhBMP-2 in large segmental defect healing in the rat femur.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Preparation and evaluation of an Arg-Gly-Asp-modified chitosan/hydroxyapatite scaffold for application in bone tissue engineering.Molecular medicine reports · 2015Article
- [Complication management for failed bone fracture healing: pseudarthrosis].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2015Review
- Biological aspects of segmental bone defects management.International orthopaedics · 2015Review
- Induced membrane for treatment of critical sized bone defect: a review of experimental and clinical experiences.International orthopaedics · 2014Review
- Advances in regenerative orthopedics.Mayo Clinic proceedings · 2013Article
- Dexamethasone induces osteogenesis via regulation of hedgehog signalling molecules in rat mesenchymal stem cells.International orthopaedics · 2013Article
- Article
- Harnessing and modulating inflammation in strategies for bone regeneration.Tissue engineering. Part B, Reviews · 2011Review
- The role of stem cells in fracture healing and nonunion.International orthopaedics · 2011Review
- Cell therapy in bone healing disorders.Orthopedic reviews · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical management of delayed healing or nonunion of long bone fractures and segmental bone defects poses a substantial orthopaedic challenge. Surgical advances and bone tissue engineering are providing new avenues to stimulate bone growth in cases of bone loss and nonunion. The reamer-irrigator-aspirator (RIA) device allows surgeons to aspirate the medullary contents of long bones and use the progenitor-rich "flow-through" fraction in autologous bone grafting. Dexamethasone (DEX) is a synthetic steroid that has been shown to induce osteoblastic differentiation. A series of 13 patients treated with RIA bone grafting enhanced with DEX for nonunion or segmental defect was examined retrospectively to assess the quality of bony union and clinical outcomes. Despite the initial poor prognoses, promising results were achieved using this technique; and given the complexity of these cases the observed success is of great value and warrants controlled study into both standardisation of the procedure and concentration of the grafting material.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.