ArticleJournal of biomedicine & biotechnology2010
Epo is relevant neither for microvascular formation nor for the new formation and maintenance of mice skeletal muscle fibres in both normoxia and hypoxia.
Article in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Insights from the use of erythropoietin in experimental Chagas disease.International journal for parasitology. Drugs and drug resistance · 2022Article
- Effect of exercise training in rats exposed to chronic hypoxia: Application for Monge's disease.Physiological reports · 2021Article
- The Many Facets of Erythropoietin Physiologic and Metabolic Response.Frontiers in physiology · 2019Review
- Disruption of Angiogenesis by Anthocyanin-Rich Extracts ofInternational journal of scientific and engineering research · 2017Article
- Erythropoietin and the use of a transgenic model of erythropoietin-deficient mice.Hypoxia (Auckland, N.Z.) · 2016Review
- HIF-1-driven skeletal muscle adaptations to chronic hypoxia: molecular insights into muscle physiology.Cellular and molecular life sciences : CMLS · 2015Review
- Chronic fetal hypoxia affects axonal maturation in guinea pigs during development: A longitudinal diffusion tensor imaging and T2 mapping study.Journal of magnetic resonance imaging : JMRI · 2015Article
- The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?Frontiers in physiology · 2013Article
- Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study.BMC medical genomics · 2012Article
- The effect of erythropoietin on normal and neoplastic cells.Biologics : targets & therapy · 2012Article
- Article
- A two-compartment model of VEGF distribution in the mouse.PloS one · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythropoietin (Epo) and vascular growth factor (VEGF) are known to be involved in the regulation of cellular activity when oxygen transport is reduced as in anaemia or hypoxic conditions. Because it has been suggested that Epo could play a role in skeletal muscle development, regeneration, and angiogenesis, we aimed to assess Epo deficiency in both normoxia and hypoxia by using an Epo-deficient transgenic mouse model (Epo-TAg(h)). Histoimmunology, ELISA and real time RT-PCR did not show any muscle fiber atrophy or accumulation of active HIF-1alpha but an improvement of microvessel network and an upregulation of VEGFR2 mRNA in Epo-deficient gastrocnemius compared with Wild-Type one. In hypoxia, both models exhibit an upregulation of VEGF120 and VEGFR2 mRNA but no accumulation of Epo protein. EpoR mRNA is not up-regulated in both Epo-deficient and hypoxic gastrocnemius. These results suggest that muscle deconditioning observed in patients suffering from renal failure is not due to Epo deficiency.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.