Evidence map›Paper›PMID 20414258›Full record

ReviewNature reviews. Molecular cell biology2010

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.

Sussan Nourshargh, Peter L Hordijk, Michael Sixt

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 283 papers.

0numbers the graph read from it
0cells of the map it votes in
283citing papers in PubMed
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

283 citing papers in PubMed, 552 citations in OpenAlex.

  1. Review
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  9. Prostaglandin EThe American journal of pathology · 2026
    Article
  10. Review
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  12. Review
  13. Article
  14. Article
  15. Review
  16. Plasticity in leukocyte migration during haematopoiesis and inflammation.Journal of muscle research and cell motility · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Review

223 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Sussan NoursharghBarts and The London School of Medicine and Dentistry, Queen Mary University of London, William Harvey Research Institute, Charterhouse Square, London, UK. s.nourshargh@qmul.ac.uk
Peter L Hordijk
Michael Sixt
Max Planck Institute of Biochemistry · DEUniversity of Amsterdam · NLWilliam Harvey Research Institute · GB

Funding

Wellcome Trust 081172/Z/06/Z
6 · The paper itself

Abstract

The shuttling of leukocytes between the bloodstream and interstitial tissues involves different locomotion strategies that are governed by locally presented soluble and cell-bound signals. Recent studies have furthered our understanding of the rapidly advancing field of leukocyte migration, particularly regarding cellular and subcellular events at the level of the venular wall. Furthermore, emerging cellular models are now addressing the transition from an adherent mode to a non-adherent state, incorporating mechanisms that support an efficient migratory profile of leukocytes in the interstitial tissue beyond the venular wall.

Indexed as

Cell MovementAnimalsBasement MembraneEndothelial CellsHumansLeukocytesPericytesVenules

Identifiers

PMID20414258
OpenAlexW2166769371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.