Evidence map›Paper›PMID 20414201›Full record

ReviewNature reviews. Cancer2010

Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma.

Jason T Huse, Eric C Holland

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03542409 (Assessment of Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas and Tumor Region-Specific Biomarker Correlation), which is not on this map. Cited by 387 papers.

0numbers the graph read from it
0cells of the map it votes in
387citing papers in PubMed
28.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03542409 early_phase1completednot on this mapstarted 2017, after this paper: background citation

Assessment of Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas and Tumor Region-Specific Biomarker Correlation

TypeinterventionalSponsorUniversity of UtahRan2017 to 2025Enrolled53ConditionsBrain Tumor AdultArmsMR Perfusion Scan, 2HG Spectroscopy Scan, Standard of Care Intraoperative MRI
3 · Its place in the literature

Who cites it

387 citing papers in PubMed, 766 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
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  8. Article
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  12. Article
  13. Development of AGT-7: An InnovativePharmaceuticals (Basel, Switzerland) · 2025
    Article
  14. Gliomagenesis following chronic subdural hematoma: A case report.Experimental and therapeutic medicine · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. The Role of RAS in CNS Tumors: A Key Player or an Overlooked Oncogene?International journal of molecular sciences · 2025
    Review
  19. Article
  20. Review

327 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jason T HuseDepartments of Pathology, 408 East 69th Street (Z1304), New York, NY 10065, USA.
Eric C Holland
Cancer Genetics (United States) · USFaculty of 1000 (United States) · US

Funding

The Role of Signaling Pathways in Brain Tumors in MiceR01CA100688 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI HOLLAND, ERIC C. · 2003 to 2013
$3.8M
NCI NIH HHS R01 CA100688
6 · The paper itself

Abstract

Malignant brain tumours continue to be the cause of a disproportionate level of morbidity and mortality across a wide range of individuals. The most common variants in the adult and paediatric populations - malignant glioma and medulloblastoma, respectively - have been the subject of increasingly intensive research over the past two decades that has led to considerable advances in the understanding of their basic biology and pathogenesis. This Review summarizes these developments in the context of the evolving notion of molecular pathology and discusses the implications that this work has on the design of new treatment regimens.

Indexed as

AnimalsBrain NeoplasmsCerebellar NeoplasmsGliomaHumansMedulloblastomaPathology, Molecular

Identifiers

PMID20414201
OpenAlexW2084170466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.