ArticleHuman heredity2010
An application of the latent p value method to assess linkage in asthma pedigrees.
Article in Human heredity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe latent p value is a recently proposed empirical method for assessing evidence against a null hypothesis in a stochastic system involving latent, unobservable variables. It is particularly applicable to genome-wide genetic linkage analysis for test statistics with poorly defined analytical distributions.
methodsWe describe an implementation of the latent p value method and its application to a linkage analysis of asthma in 81 extended pedigrees containing 1,858 people genotyped at 533 microsatellite markers. We compare the performance of the latent p value method to a more conventional p value calculation. We also compare the performance of various linkage statistics within this pedigree resource.
resultsUsing a novel linkage score referred to as the C-link statistic, our analysis provides strong evidence for a recessive gene influencing asthma on chromosome 5q13 (median latent p value = 0.03). We also demonstrate remarkable improvement in computational requirements compared to a more conventional empirical p value calculation.
conclusionsThe latent p value method is indeed feasible and provides a computationally efficient means to evaluate evidence for linkage regardless of the choice of linkage statistic.
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