ArticleThe Journal of molecular diagnostics : JMD2010
A real-time PCR assay for the simultaneous detection of functional N284I and L412F polymorphisms in the human Toll-like receptor 3 gene.
Article in The Journal of molecular diagnostics : JMD, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Host genetic factors modulating dengue virus: a systematic review of TLR polymorphisms.BMC infectious diseases · 2026Pooled it
- "In silico analysis of human TLR3 missense single nucleotide polymorphisms and their potential association with cancer".Scientific reports · 2025Article
- Article
- Article
- TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFROncoimmunology · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Toll-like receptors (TLR) serve important roles in immunity against microbial pathogens, and TLR3 plays a critical role in the recognition of double-stranded RNA derived from viruses. Two specific single nucleotide polymorphisms (SNP) in the human TLR3 gene, A851T and C1234T, which result in amino acid substitutions, N284I and L412F, respectively, have been described to result in impaired receptor signaling and function in an in vitro model. Hence, an assay that could simultaneously detect these two functional TLR3 SNPs could facilitate studies into their role in the pathogenesis of human viral diseases and serve as a tool to screen viral disease predisposition. Therefore, we developed a real-time PCR assay based on a LightCycler format for simultaneous detection of A851T and C1234T SNPs within the TLR3 gene. This relatively low-cost PCR assay is proposed as a novel tool in the study of TLR3 and its role in viral disease.
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Registered trials
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