ArticleAmerican journal of respiratory and critical care medicine2010
Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing {gamma}{delta}T cells.
Article in American journal of respiratory and critical care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 99 citations in OpenAlex.
- γδ T Cells Are Required for the Induction of Sterile Immunity during Irradiated Sporozoite Vaccinations.Journal of immunology (Baltimore, Md. : 1950) · 2017Trial
- Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma.Mucosal immunology · 2016Trial
- The Role of Innate T Cells in Inflammatory Disorders in Asthma and Chronic Rhinosinusitis.Clinical and experimental otorhinolaryngology · 2026Review
- Mechanisms and Functions of γδ T Cells in Tumor Cell Recognition.Current oncology (Toronto, Ont.) · 2025Review
- γδ T Cells and Allergic Diseases.Clinical reviews in allergy & immunology · 2023Review
- Combining bioinformatics and machine learning to identify common mechanisms and biomarkers of chronic obstructive pulmonary disease and atrial fibrillation.Frontiers in cardiovascular medicine · 2023Article
- Tissue-resident immunity in the lung: a first-line defense at the environmental interface.Seminars in immunopathology · 2022Review
- Beneficial effects of infrared light-emitting diode in corticosteroid-resistant asthma.Lasers in medical science · 2022Article
- Effects of immunosuppressants on T-cell dynamics: Understanding from a generic coarse-grained immune network model.Journal of biosciences · 2022Review
- Interleukin-17A and interleukin-22 production by conventional and non-conventional lymphocytes in three different end-stage lung diseases.Clinical & translational immunology · 2022Article
- Review
- γδ T Lymphocytes in Asthma: a Complicated Picture.Archivum immunologiae et therapiae experimentalis · 2021Review
- Treatment options in type-2 low asthma.The European respiratory journal · 2021Review
- Mucosal Associated Invariant T Cells Were Activated and Polarized Toward Th17 in Chronic Obstructive Pulmonary Disease.Frontiers in immunology · 2021Article
- New Insights into Asthma Inflammation: Focus on iNKT, MAIT, and γδT Cells.Clinical reviews in allergy & immunology · 2020Review
- Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung.Nature immunology · 2020Article
- IL33 contributes to diesel pollution-mediated increase in experimental asthma severity.Allergy · 2020Article
- The role of interleukin-17 in asthma: a protective response?ERJ open research · 2020Review
- Intrinsically altered lung-resident γδT cells control lung melanoma by producing interleukin-17A in the elderly.Aging cell · 2020Article
- Enterovirus D68 infection induces IL-17-dependent neutrophilic airway inflammation and hyperresponsiveness.JCI insight · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
rationalegammadeltaT lymphocytes are enriched within the epithelial microenvironment, where they are thought to maintain homeostasis and limit immunopathology. gammadeltaT cells are postulated to exert a regulatory influence during acute allergic airway disease, but the mechanism is unknown. Although regulation of allergic airway disease has been attributed to IL-17-producing T helper (Th) 17 cells, we have found that gammadeltaT cells represent the major source of IL-17 in the allergic lung.
objectivesThe aim of this study was to determine the contribution of these IL-17-producing gammadeltaT cells to regulation of allergic airway inflammation.
methodsFlow cytometry revealed that IL-17-producing gammadeltaT cells are more prevalent than IL-17(+)alphabetaT cells (Th17) in a murine model of ovalbumin-induced allergic inflammation. MEASUREMENTS AND MAIN
resultsTransfer of gammadeltaT cells at the peak of acute allergic responses ameliorated airway hyperresponsiveness with a corresponding acceleration in the resolution of eosinophilic and Th2-driven inflammation. Conversely, functional blockade of gammadeltaT cells led to exacerbation of injury. Neither treatment changed pulmonary Th17 cell numbers. Moreover, transfer of Th17 cells had no effect on disease outcome. Importantly, IL-17-deficient gammadeltaT cells were unable to promote resolution of injury. These data identify IL-17-producing gammadeltaT cells as key regulators of the allergic response in vivo.
conclusionsThis unfolds a new perspective for the understanding of gammadeltaT cell function with regard to innate regulation of the adaptive immune responses, emphasizing that resolution of responses are important in determining the outcome of acute inflammatory episodes as well as for maintenance of tissue integrity and homeostasis.
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