ArticleClinical journal of the American Society of Nephrology : CJASN2010
Pregnancy and chronic kidney disease: a challenge in all CKD stages.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Pregnancy after living kidney donation, a systematic review of the available evidence, and a review of the current guidance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Pooled it
- Maternal and neonatal outcomes of pregnancy complicated by urolithiasis: a systematic review and meta-analysis.Journal of nephrology · 2021Pooled it
- A best-practice position statement on pregnancy after kidney transplantation: focusing on the unsolved questions. The Kidney and Pregnancy Study Group of the Italian Society of Nephrology.Journal of nephrology · 2018Guideline
- A best practice position statement on the role of the nephrologist in the prevention and follow-up of preeclampsia: the Italian study group on kidney and pregnancy.Journal of nephrology · 2017Guideline
- A Systematic Review and Meta-Analysis of Outcomes of Pregnancy in CKD and CKD Outcomes in Pregnancy.Clinical journal of the American Society of Nephrology : CJASN · 2015Pooled it
- Type 1 diabetes, diabetic nephropathy, and pregnancy: a systematic review and meta-study.The review of diabetic studies : RDS · 2013Pooled it
- Pregnancy outcomes in women with chronic kidney disease: a systematic review.Clinical journal of the American Society of Nephrology : CJASN · 2011Pooled it
- Impact of maternal health on neonatal and long-term kidney outcomes.Pediatric nephrology (Berlin, Germany) · 2026Review
- Article
- Laboratory Signs of CKD after Preeclampsia.Journal of the American Society of Nephrology : JASN · 2026Article
- Multifetal Pregnancies in Women with CKD: Risk Assessment and Indications for Counseling.Kidney360 · 2026Article
- Pregnancy in Patients With Renal Transplant.O&G open · 2026Review
- Pregnancy outcomes and risk factors analysis in patients with chronic kidney disease: a nested case-control study.BMC pregnancy and childbirth · 2026Article
- Clinical Course and Considerations of a Stage G4 Chronic Kidney Disease Patient Who Successfully Initiated Dialysis During Pregnancy and Discontinued It Postpartum.The American journal of case reports · 2026Article
- The Prognostic Significance of Proteinuria Severity in Pregnancy: A Retrospective Cohort Study of Maternal and Neonatal Outcomes.Journal of clinical medicine · 2026Article
- Kidney Replacement Therapy Within 12 Months of Childbirth in Australia.Kidney international reports · 2026Article
- Early-mid pregnancy renal parameters and adverse pregnancy outcomes in women with early stage CKD: a case series.Journal of nephrology · 2025Article
- Advanced maternal age, gestational diabetes, renal function, and obesity in hypertensive disorders of pregnancy: are we missing key risk factors?Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Assessing the risk of preeclampsia/eclampsia in Mississippi black women with chronic kidney disease using electronic health records.Pregnancy hypertension · 2025Article
- Dialysis During Pregnancy: Are We Any Closer to Clarity?Kidney international reports · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesChronic kidney disease (CKD) is a challenge for pregnancy. Its recent classification underlines the importance of its early phases. This study's aim was to evaluate outcomes of pregnancy according to CKD stage versus low-risk pregnancies followed in the same center. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The prospective analysis was conducted from January 2000 to May 2009 with the start of observation at referral and end of observation 1 month after delivery. Ninety-one singleton deliveries were studied; 267 "low-risk" singleton pregnancies served as controls. Because of the lack of hard end points (death, start of dialysis), surrogate end points were analyzed (cesarean section, prematurity, neonatal intensive care).
resultsCKD outcome was worse than physiologic pregnancies: preterm delivery (44% versus 5%); cesarean section (44% versus 25%); and need for neonatal intensive care (26% versus 1%). The differences were highly significant in stage 1 CKD (61 cases) versus controls (CKD stage 1: cesarean sections = 57%, preterm delivery = 33%, intensive care = 18%). In CKD, proteinuria and hypertension were correlated with outcomes [proteinuria dichotomized at 1 g/24 h at referral: need for intensive care, relative risk (RR) = 4.16 (1.05 to 16.46); hypertension: preterm delivery, RR = 7.24 (2.30 to 22.79); cesarean section, RR = 5.70 (1.69 to 19.24)]. Statistical significance across stages was reached for preterm delivery [RR = 3.32 (1.09 to 10.13)].
conclusionsCKD is a challenge for pregnancy from early stages. Strict follow-up is needed for CKD patients, even when there is normal renal function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.