ArticlePsychiatry research2010
Brain glutamatergic characteristics of pediatric offspring of parents with bipolar disorder.
Article in Psychiatry research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies.Journal of psychiatry & neuroscience : JPN · 2012Pooled it
- Neurofunctional Correlates of Response to Quetiapine in Adolescents with Bipolar Depression.Journal of child and adolescent psychopharmacologyTrial
- Biological factors contributing to divergent cortical abnormalities in adolescent and adult psychiatric disorders.Translational psychiatry · 2026Article
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- Individual prediction of symptomatic converters in youth offspring of bipolar parents using proton magnetic resonance spectroscopy.European child & adolescent psychiatry · 2021Article
- Localized MRS reliability of in vivo glutamate at 3 T in shortened scan times: a feasibility study.NMR in biomedicine · 2017Article
- Vitamin D3 Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders.Journal of child and adolescent psychopharmacology · 2015Article
- A review of MR spectroscopy studies of pediatric bipolar disorder.AJNR. American journal of neuroradiology · 2014Review
- Prospective neurochemical characterization of child offspring of parents with bipolar disorder.Psychiatry research · 2013Article
- The neural effects of psychotropic medications in children and adolescents.Child and adolescent psychiatric clinics of North America · 2012Review
- Neural recruitment during failed motor inhibition differentiates youths with bipolar disorder and severe mood dysregulation.Biological psychology · 2012Article
- A magnetic resonance spectroscopy study of the anterior cingulate cortex in youth with emotional dysregulation.The Israel journal of psychiatry and related sciences · 2012Article
- Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder.Bipolar disorders · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We wished to determine whether decreases in prefrontal glutamate concentrations occur in offspring of parents with bipolar disorder with and at high risk for mania. Sixty children and adolescents, 9-18 years old, of parents with bipolar I or II disorder (20 offspring with established history of mania, "BD", 20 offspring with symptoms subsyndromal to mania, "SS", and 20 healthy controls "HC") were examined using proton magnetic resonance spectroscopy at 3T to study glutamatergic metabolite concentrations in the anterior cingulate cortex (ACC). A signal for reductions in absolute glutamate concentrations in the ACC was seen in the BD compared with HC and SS groups. No other statistically significant differences among groups were found. Offspring of parents with BD with prior histories of mania may have disruptions in glutamatergic function compared with HC or children at risk for BD who have not yet developed mania. Longitudinal studies are necessary to confirm whether prefrontal glutamate decreases only after the onset of full mania.
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Registered trials
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