ArticleComparative medicine2010
Use of biomarkers of collagen types I and III fibrosis metabolism to detect cardiovascular and renal disease in chimpanzees (Pan troglodytes).
Article in Comparative medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Discovery of novel biomarkers associated with myocardial fibrosis in chimpanzees (Frontiers in veterinary science · 2026Article
- Early Myocardial Strain Reduction and miR-122-5p Elevation Associated with Interstitial Fibrosis in Anthracycline-Induced Cardiotoxicity.Biomedicines · 2024Article
- Standardizing urethral stricture models in rats: a comprehensive study on histomorphologic and molecular approach.International urology and nephrology · 2024Article
- Optimizing Selection of the Reference Population for Genotype Imputation From Array to Sequence Variants.Frontiers in genetics · 2019Article
- Effect of Kangxianling Decoction on Expression of TGF-Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Anti-fibrotic effect of rosmarinic acid on inhibition of pterygium epithelial cells.International journal of ophthalmology · 2018Article
- QiShenYiQi Attenuates Renal Interstitial Fibrosis by Blocking the Activation of β-Catenin.PloS one · 2016Article
- Imaging Fibrosis and Separating Collagens using Second Harmonic Generation and Phasor Approach to Fluorescence Lifetime Imaging.Scientific reports · 2015Article
- Astragalus membranaceus inhibits peritoneal fibrosis via monocyte chemoattractant protein (MCP)-1 and the transforming growth factor-β1 (TGF-β1) pathway in rats submitted to peritoneal dialysis.International journal of molecular sciences · 2014Article
- Article
- Fatal myocardial fibrosis in an aged chimpanzee (Pan troglodytes).Pathobiology of aging & age related diseases · 2013Article
- Censored Data Analysis Reveals Effects of Age and Hepatitis C Infection on C-Reactive Protein Levels in Healthy Adult Chimpanzees (Pan troglodytes).Journal of biomarkers · 2013Article
- Immunophenotypic alterations in resident immune cells and myocardial fibrosis in the aging rhesus macaque (Macaca mulatta) heart.Toxicologic pathology · 2012Article
- Chronic diseases in captive geriatric female Chimpanzees (Pan troglodytes).Comparative medicine · 2012Article
- Effects of aging and blood contamination on the urinary protein-creatinine ratio in captive chimpanzees (Pan troglodytes).Journal of the American Association for Laboratory Animal Science : JAALAS · 2011Article
- Association of brain-type natriuretic protein and cardiac troponin I with incipient cardiovascular disease in chimpanzees (Pan troglodytes).Comparative medicine · 2011Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Cardiovascular disease is the leading cause of morbidity and mortality among captive chimpanzees. The most prevalent form of cardiovascular disease among chimpanzees is sudden cardiac death. Myocardial fibrosis was the only significant pathologic lesion observed in affected animals at necropsy. We previously showed an association between myocardial fibrosis and sudden cardiac death. The presumed pathogenesis was interstitial myocardial fibrosis that led to decreased myocardial contractility and interrupted signal propagation in the heart, leading to fibrillation and resulting in sudden cardiac death. In this pilot study, we assayed 5 biomarkers of collagen types I and III metabolism and fibrogenesis and studied their association with CVD in chimpanzees. The biomarker MMP1 did not crossreact in chimpanzee sera and could not be studied further. Two biomarkers (TIMP1 and PINP) and their difference showed no significant association with CVD in chimpanzees. The biomarkers ICTP and PIIINP were significantly increased in cases of CVD with concurrent renal disease. Furthermore, both biomarkers showed a significant trend to increase with disease severity. We conclude that ICTP and PIIINP warrant further study for antemortem detection of renal and myocardial fibrosis in chimpanzees.
Indexed as
Identifiers
20412692PMC2855044W1571431444What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.