ArticleMalaria journal2010
Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression.
Article in Malaria journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Metabolomics Insights into Salivary Profile in Dogs withBiomolecules · 2025Article
- Host metabolomic responses in recurrent P. vivax malaria.Scientific reports · 2024Article
- Harnessing Schistosoma-associated metabolite changes in the human host to identify biomarkers of infection and morbidity: Where are we and what should we do next?PLoS neglected tropical diseases · 2024Review
- Investigation of urine metabolome of BALB/c mouse infected with an avirulent strain of Toxoplasma gondii.Parasites & vectors · 2022Article
- Early Perturbations in Glucose Utilization in Malaria-Infected Murine Erythrocytes, Liver and Brain Observed by Metabolomics.Metabolites · 2020Article
- Mining the Human Host Metabolome Toward an Improved Understanding of Malaria Transmission.Frontiers in microbiology · 2020Review
- Metabolome-wide association study of peripheral parasitemia in Plasmodium vivax malaria.International journal of medical microbiology : IJMM · 2017Article
- Cloning and in vitro characterization of a Schistosoma japonicum aquaglyceroporin that functions in osmoregulation.Scientific reports · 2016Article
- Aquaglyceroporin function in the malaria mosquito Anopheles gambiae.Biology of the cell · 2016Article
- Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds.Journal of translational medicine · 2016Article
- Metabolic Signature Profiling as a Diagnostic and Prognostic Tool in Pediatric Plasmodium falciparum Malaria.Open forum infectious diseases · 2015Article
- Metabolomics in the fight against malaria.Memorias do Instituto Oswaldo Cruz · 2014Review
- Article
- Application of NMR metabolomics to search for human disease biomarkers.Combinatorial chemistry & high throughput screening · 2012Review
- Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum.The Journal of infectious diseases · 2012Article
- Analysis of bacterial biofilms using NMR-based metabolomics.Future medicinal chemistry · 2012Review
- Global host metabolic response to Plasmodium vivax infection: a 1H NMR based urinary metabonomic study.Malaria journal · 2011Article
- Multivariate modelling with (1)H NMR of pleural effusion in murine cerebral malaria.Malaria journal · 2011Article
- Central carbon metabolism of Plasmodium parasites.Molecular and biochemical parasitology · 2011Review
- Metabolomics and malaria biology.Molecular and biochemical parasitology · 2011Review
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolic changes in the host in response to Plasmodium infection play a crucial role in the pathogenesis of malaria. Alterations in metabolism of male and female mice infected with Plasmodium berghei ANKA are reported here.
methods1H NMR spectra of urine, sera and brain extracts of these mice were analysed over disease progression using Principle Component Analysis and Orthogonal Partial Least Square Discriminant Analysis.
resultsAnalyses of overall changes in urinary profiles during disease progression demonstrate that females show a significant early post-infection shift in metabolism as compared to males. In contrast, serum profiles of female mice remain unaltered in the early infection stages; whereas that of the male mice changed. Brain metabolite profiles do not show global changes in the early stages of infection in either sex. By the late stages urine, serum and brain profiles of both sexes are severely affected. Analyses of individual metabolites show significant increase in lactate, alanine and lysine, kynurenic acid and quinolinic acid in sera of both males and females at this stage. Early changes in female urine are marked by an increase of ureidopropionate, lowering of carnitine and transient enhancement of asparagine and dimethylglycine. Several metabolites when analysed individually in sera and brain reveal significant changes in their levels in the early phase of infection mainly in female mice. Asparagine and dimethylglycine levels decrease and quinolinic acid increases early in sera of infected females. In brain extracts of females, an early rise in levels is also observed for lactate, alanine and glycerol, kynurenic acid, ureidopropionate and 2-hydroxy-2-methylbutyrate.
conclusionsThese results suggest that P. berghei infection leads to impairment of glycolysis, lipid metabolism, metabolism of tryptophan and degradation of uracil. Characterization of early changes along these pathways may be crucial for prognosis and better disease management. Additionally, the distinct sexual dimorphism exhibited in these responses has a bearing on the understanding of the pathophysiology of malaria.
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