ArticleBMC neuroscience2010
Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of doublecortin and NCAM-180.
Article in BMC neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Free Thyroxine (fT4) as a Potential Biomarker of Neurological and Functional Outcome in Acquired Brain Injury: A Prospective Multicenter Cohort Study.Journal of clinical medicine · 2023Article
- Thyroid function and epilepsy: a two-sample Mendelian randomization study.Frontiers in human neuroscience · 2023Article
- Lissencephaly with Congenital Hypothyroidism: A Case Report.JNMA; journal of the Nepal Medical Association · 2022Article
- Neuronal Nitric Oxide Inhibitor 7-Nitroindazole Improved Brain-Derived Neurotrophic Factor and Attenuated Brain Tissues Oxidative Damage and Learning and Memory Impairments of Hypothyroid Juvenile Rats.Neurochemical research · 2020Article
- Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke.Frontiers in neurology · 2019Review
- Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: A stereological study.Metabolic brain disease · 2017Article
- Suggested use of sensitive measures of memory to detect functional effects of maternal iodine supplementation on hippocampal development.The American journal of clinical nutrition · 2016Article
- Music application alleviates short-term memory impairments through increasing cell proliferation in the hippocampus of valproic acid-induced autistic rat pups.Journal of exercise rehabilitation · 2016Article
- Thyroid hormone signaling: Contribution to neural function, cognition, and relationship to nicotine.Neuroscience and biobehavioral reviews · 2015Review
- The Ever-Changing Morphology of Hippocampal Granule Neurons in Physiology and Pathology.Frontiers in neuroscience · 2015Article
- Brain Tissues Oxidative Damage as A Possible Mechanism of Deleterious Effects of Propylthiouracil- Induced Hypothyroidism on Learning and Memory in Neonatal and Juvenile Growth in Rats.Basic and clinical neuroscience · 2014Article
- Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice.Development (Cambridge, England) · 2014Article
- Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring.BMC neuroscience · 2012Article
- Cocaine decreases expression of neurogranin via alterations in thyroid receptor/retinoid X receptor signaling.Journal of neurochemistry · 2012Article
- Hypothyroidism stimulates D2 receptor-mediated breathing in response to acute hypoxia and alters D2 receptors levels in carotid bodies and brain.Respiratory physiology & neurobiology · 2012Article
- Hypothyroidism attenuates SCH 23390-mediated depression of breathing and decreases D1 receptor expression in carotid bodies, PVN and striatum of hamsters.Brain research · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDevelopmental iodine deficiency results in inadequate thyroid hormone (TH), which damages the hippocampus. Here, we explored the roles of hippocampal doublecortin and neural cell adhesion molecule (NCAM)-180 in developmental iodine deficiency and hypothyroidism.
methodsTwo developmental rat models were established with either an iodine-deficient diet, or propylthiouracil (PTU)-adulterated water (5 ppm or 15 ppm) to impair thyroid function, in pregnant rats from gestational day 6 until postnatal day (PN) 28. Silver-stained neurons and protein levels of doublecortin and NCAM-180 in several hippocampal subregions were assessed on PN14, PN21, PN28, and PN42.
resultsThe results show that nerve fibers in iodine-deficient and 15 ppm PTU-treated rats were injured on PN28 and PN42. Downregulation of doublecortin and upregulation of NCAM-180 were observed in iodine-deficient and 15 ppm PTU-treated rats from PN14 on. These alterations were irreversible by the restoration of serum TH concentrations on PN42.
conclusionDevelopmental iodine deficiency and hypothyroidism impair the expression of doublecortin and NCAM-180, leading to nerve fiber malfunction and thus impairments in hippocampal development.
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