ArticleJournal of thrombosis and haemostasis : JTH2010
Neutrophil granulocyte-dependent proteolysis enhances platelet adhesion to the arterial wall under high-shear flow.
Article in Journal of thrombosis and haemostasis : JTH, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Interaction of von Willebrand factor with blood cells in flow models: a systematic review.Blood advances · 2022Pooled it
- 3D culturing of human pluripotent stem cells-derived endothelial cells for vascular regeneration.Theranostics · 2022Article
- Cryopreservation moderates the thrombogenicity of arterial allografts during storage.PloS one · 2021Article
- High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis.Regenerative biomaterials · 2016Review
- Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases?World journal of cardiology · 2015Review
- Is the neutrophil a 'prima donna' in the procoagulant process during sepsis?Critical care (London, England) · 2014Review
- Mechanical stability and fibrinolytic resistance of clots containing fibrin, DNA, and histones.The Journal of biological chemistry · 2013Article
- Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components.Journal of thrombosis and haemostasis : JTH · 2013Article
- Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.PloS one · 2013Article
- Modulation of the von Willebrand factor-dependent platelet adhesion through alternative proteolytic pathways.Thrombosis research · 2012Article
- Neutrophils release brakes of coagulation.Nature medicine · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
SUMMARY
backgroundUnder high shear stress platelets adhere preferentially to the adventitia layer of the arterial vessel wall in a von Willebrand factor (VWF)-dependent manner.
objectiveThe present study was undertaken in an attempt to characterize the structural background of the relative thromboresistance of the media and the impact of neutrophil leukocyte-derived proteases (matrix metalloproteinases, neutrophil elastase) on platelet adhesion in this layer of the arteries. METHODS AND
resultsPlatelet adhesion to cross-sections of the human iliac artery was monitored by indirect immunofluorescent detection of GpIIb/IIIa antigen. Exposure of the vessel wall to activated neutrophils or neutrophil-derived proteases increased platelet adhesion to the media about tenfold over the control level at 3350 s(-1) surface shear rate. In parallel with this enhanced thrombogenicity morphological changes in the media were evidenced by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The fine proteoglycan meshwork seen with Cupromeronic Blue enhancement of the SEM images was removed by the proteolytic treatment and the typical collagen fiber structure was exposed on the AFM images of the media.
conclusionThrough their proteases activated neutrophils degrade proteoglycans, unmask VWF binding sites and thus abolish the thromboresistance of the media in human arteries.
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Registered trials
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