ArticleEuropean journal of immunology2010
Modulating numbers and phenotype of CD8+ T cells in secondary immune responses.
Article in European journal of immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 37 citations in OpenAlex.
- SARS-CoV-2 inflammation durably imprints memory CD4 T cells.Science immunology · 2024Article
- Immunotherapies landscape and associated inhibitors for the treatment of cervical cancer.Medical oncology (Northwood, London, England) · 2023Review
- Inflammation durably imprints memory CD4+ T cells.bioRxiv : the preprint server for biology · 2023Article
- Maintenance and recall of memory T cell populations against tuberculosis: Implications for vaccine design.Frontiers in immunology · 2023Review
- Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice.PLoS pathogens · 2020Article
- Clofazimine enhances the efficacy of BCG revaccination via stem cell-like memory T cells.PLoS pathogens · 2020Article
- Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.Cell reports · 2020Article
- Curcumin Nanoparticles Enhance Mycobacterium bovis BCG Vaccine Efficacy by Modulating Host Immune Responses.Infection and immunity · 2019Article
- Dendritic Cell Cancer Therapy: Vaccinating the Right Patient at the Right Time.Frontiers in immunology · 2018Review
- Effector functions of memory CTLs can be affected by signals received during reactivation.Immunologic research · 2017Article
- Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice.Frontiers in immunology · 2017Article
- Article
- Signaling in T cells - is anything the m(a)TOR with the picture(s)?F1000Research · 2016Review
- The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.PLoS pathogens · 2015Article
- Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses.Seminars in immunopathology · 2015Review
- The longevity of memory CD8 T cell responses after repetitive antigen stimulations.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Topical CpG adjuvantation of a protein-based vaccine induces protective immunity to Listeria monocytogenes.Clinical and vaccine immunology : CVI · 2014Article
- Cutting edge: Expression of FcγRIIB tempers memory CD8 T cell function in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Effector-like CD8⁺ T cells in the memory population mediate potent protective immunity.Immunity · 2013Article
- Cutting edge: rapid boosting of cross-reactive memory CD8 T cells broadens the protective capacity of the Flumist vaccine.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Prime-boost regimens are frequently used to increase the number of memory CD8(+) T cells and thus the protective capacity of experimental vaccinations; however, it is currently unknown how the frequency and phenotype of primary (1 degrees ) memory CD8(+) T cells impact the quantity and phenotype of secondary (2 degrees ) memory CD8(+) T-cell populations. Here, we show that 2 degrees infections of mice that received different 1 degrees infections and/or immunizations generated similar numbers of 2 degrees effector and memory CD8(+) T cells. Remarkably, this result was independent of the numbers and phenotype of 1 degrees memory CD8(+) T cells present at the time of rechallenge. However, after adoptive transfer of low numbers of 1 degrees memory CD8(+) T cells, a linear correlation between 1 degrees memory CD8(+) T-cell input and 2 degrees memory CD8(+) T-cell numbers was observed. These data suggest that, above a very low threshold, boosting of 1 degrees memory CD8(+) T-cell populations elicits 2 degrees immune responses of similar magnitude. Therefore, our study has important implications for the design of prime-boost regimens that aim to generate protective CD8(+) T-cell-mediated immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.