Evidence map›Paper›PMID 20411366›Full record

SynthesisMedical oncology (Northwood, London, England)2011

Physical activity and survival after breast cancer diagnosis: meta-analysis of published studies.

Ezzeldin M Ibrahim, Abdelaziz Al-Homaidh

5 registry-linked trialsAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Medical oncology (Northwood, London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 274 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 17 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03045575 completednot on this mapstarted 2016, after this paper: background citation

Objective Assessment of Physical Activity During Chemotherapy for Breast Cancer

TypeobservationalSponsorUniversity of California, San FranciscoRan2016 to 2018Enrolled65ConditionsBreast Cancer
NCT03529383 nacompletednot on this mapstarted 2018, after this paper: background citation

Randomized Controlled Trial Evaluating the Efficacy of an Adapted Physical Activity Program Using a Connected Device With Activity Trackers and a Therapeutic Education Program Among Women With Localized Breast Cancer

TypeinterventionalSponsorCentre Leon BerardRan2018 to 2022Enrolled436ConditionsBreast CancerArmsConnected device, Therapeutic education
NCT03860740 completednot on this mapstarted 2016, after this paper: background citation

Effect of Physical Exercise on Ki-67 Levels in Women With Operable Breast Cancer Hormonal Receptor Positive, HER2 Negative

TypeobservationalSponsorSpanish Breast Cancer Research GroupRan2016 to 2021Enrolled12ConditionsBreast Cancer, Luminal BArmsExercise, Stretching
NCT05931874 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Fit2ThriveMIND: Optimizing a mHealth Physical Activity Intervention With Mindful Awareness Lessons in Breast Cancer Survivors

TypeinterventionalSponsorNorthwestern UniversityRan2024 to 2027Enrolled304ConditionsBreast CancerArmsCore Intervention, E-Coach, Buddy, General Mindfulness Training, MVPA-Specific Mindfulness Training
NCT06565858 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Can Cardiac Muscle Contraction Explain the Rarity of Tumors in the Heart?

TypeobservationalSponsorEuropean Institute of OncologyRan2024 to 2026Enrolled750ConditionsSarcoma
3 · Its place in the literature

Who cites it

274 citing papers in PubMed, 17 syntheses or guidelines pooled it, 606 citations in OpenAlex.

  1. The Effects of Post-diagnosis Recreational Aerobic Exercise among Breast Cancer Survivors: A Systematic Review/Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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  11. The requirements of a specialist breast centre.Breast (Edinburgh, Scotland) · 2020
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  12. Effects of exercise on the quality of life in breast cancer patients: a systematic review of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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  13. Physical activity programming and counseling preferences among cancer survivors: a systematic review.The international journal of behavioral nutrition and physical activity · 2018
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  14. Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018
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214 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ezzeldin M IbrahimOncology Center, International Medical Center, PO Box 2172, Jeddah, 21451, Kingdom of Saudi Arabia, ezzibrahim@imc.med.sa.
Abdelaziz Al-Homaidh
King Abdullah International Medical Research Center · SAPrince Sultan University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Published data have shown that physical activity (PA) has a positive role on the primary prevention of breast cancer risk. However, the role of PA on breast cancer outcome has been controversial with inconsistent data. The lack of a meta-analysis that addresses that issue prompted the current report. A comprehensive literature search identified eight studies, of which two studies were excluded. The remaining six studies (12,108 patients with breast cancer) were included in this meta-analysis. Pre-diagnosis PA reduced all causes mortality by 18% but had no effect on breast cancer deaths. Post-diagnosis PA reduced breast cancer deaths by 34% (HR=0.66, 95% CI, 0.57-0.77, P<0.00001), all causes mortality by 41% (HR=0.59, 95% CI, 0.53-0.65, P<0.00001), and disease recurrence by 24% (HR=0.76, 95% CI, 0.66-0.87, P=0.00001). Breast cancer mortality was reduced by pre-diagnosis PA in women with body mass index (BMI)<25 kg/m2, while post-diagnosis PA reduced that risk among those with BMI≥25 kg/m2. On the other hand, post-diagnosis PA reduced all causes mortality regardless of the BMI. The analysis showed that post-diagnosis PA reduced breast cancer deaths (HR=0.50, 95% CI, 0.34-0.74, P=0.0005), and all causes mortality (HR=0.36, 95% CI, 0.12-1.03, P=0.06) among patients with estrogen receptor (ER)-positive tumor, while women with ER-negative disease showed no gain. The current meta-analysis provides evidence for an inverse relationship between PA and mortality in patients with breast cancer and supports the notion that appropriate PA should be embraced by breast cancer survivors.

Indexed as

Breast NeoplasmsExerciseFemaleHumans

Identifiers

PMID20411366
OpenAlexW2136405350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.