ArticleJournal of molecular neuroscience : MN2010
The role of transient receptor potential vanilloid 1 (TRPV1) receptors in dextran sulfate-induced colitis in mice.
Article in Journal of molecular neuroscience : MN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury.Neural regeneration research · 2025Article
- Article
- Ion channel regulation of gut immunity.The Journal of general physiology · 2023Article
- A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model.Scientific data · 2022Article
- Article
- The gut, its microbiome, and the brain: connections and communications.The Journal of clinical investigation · 2021Review
- Inhibition of transient receptor potential vanilloid 1 (TRPV1) channel regulates chikungunya virus infection in macrophages.Archives of virology · 2021Article
- Gain of Function of Ion Channel TRPV1 Exacerbates Experimental Colitis by Promoting Dendritic Cell Activation.Molecular therapy. Nucleic acids · 2020Article
- Transient Receptor Potential Channels and Inflammatory Bowel Disease.Frontiers in immunology · 2020Review
- TRPV1 in experimental autoimmune prostatitis.The Prostate · 2020Article
- Role of TRPV1 and TRPA1 Ion Channels in Inflammatory Bowel Diseases: Potential Therapeutic Targets?Pharmaceuticals (Basel, Switzerland) · 2019Review
- Effect of cold and hot compress on neutrophilic migration to the site of doxorubicin extravasation.International journal of clinical and experimental pathology · 2019Article
- TRPA1 and substance P mediate stress induced duodenal lesions in water immersion restraint stress rat model.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis.Mediators of inflammation · 2018Article
- Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence.Journal of internal medicine · 2017Review
- Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain.Scientific reports · 2016Article
- TRP channel functions in the gastrointestinal tract.Seminars in immunopathology · 2016Review
- Crosstalk between the nociceptive and immune systems in host defence and disease.Nature reviews. Neuroscience · 2015Review
- TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP.Mucosal immunology · 2015Article
- Thermal spring water drinking attenuates dextran-sulfate-sodium-induced colitis in mice.Inflammopharmacology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the involvement of transient receptor potential vanilloid 1 (TRPV1) receptors in oral dextran sulfate sodium-induced (DSS) colitis using TRPV1 knockout mice and their wild-type C57BL/6 counterparts. DSS (2% or 5%) was administered orally ad libitum for 7 days; the controls received tap water. Animal weight, stool consistency, and blood content were scored every day to calculate the disease activity index (DAI). After sacrificing the mice on day 7, the colons were cut into three equal segments (proximal, intermediate, and distal) for histology, myeloperoxidase (MPO), and cytokine measurements. In the 2% DSS-treated group, the lack of TRPV1 receptors decreased the DAI. Each colon segment of wild-type animals showed more than two-fold increase of MPO activity and more severe histological changes compared to the knockouts. This difference was not observed in case of 5% DSS, when extremely severe inflammation occurred in both groups. IL-1beta production was not altered by the absence of TRPV1. In conclusion, activation of TRPV1 channels enhances the clinical symptoms, histopathological changes, and neutrophil accumulation induced by 2% DSS. Elucidating the modulator role of TRPV1 channels in inflammatory bowel diseases may contribute to the development of novel anti-inflammatory drugs for their therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.