Evidence map›Paper›PMID 20411320›Full record

ReviewAngiogenesis2010

Theragnostics for tumor and plaque angiogenesis with perfluorocarbon nanoemulsions.

G M Lanza, P M Winter, S D Caruthers, M S Hughes, Grace Hu, A H Schmieder, S A Wickline

Abstract readReview
In one paragraph

Review in Angiogenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Perfluorocarbons-BasedInternational journal of nanomedicine · 2020
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Recent Advances inEngineering (Beijing, China) · 2015
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

G M LanzaDivision of Cardiology, Department of Medicine, Washington University Medical School, 4320 Forest Park Ave, Suite 101, St. Louis, MO 63108, USA. greg@cvu.wustl.edu
P M Winter
S D Caruthers
M S Hughes
Grace Hu
A H Schmieder
S A Wickline

Funding

UIUC Nanomaterials & Nanofabrication for Targeting CancerU54CA119342 · NCI · WASHINGTON UNIVERSITY · PI SEPT, DAVID · 2005 to 2009
$16.5M
METHODS IN MOLECULAR IMAGING AND TARGETED THERAPEUTICSR01HL073646 · NHLBI · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2004 to 2016
$13.7M
Fibrin-Specific Thrombolytic Nanoparticles for Acute StrokeR01NS059302 · NINDS · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M · 2007 to 2011
$1.7M
Combined Therapeutic-Imaging Agent for AtherosclerosisR01HL078631 · NHLBI · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M · 2004 to 2007
$1.5M
COLLOIDAL IRON-OXIDE NANOBEACONS FOR THERANOSTIC USE IN ATHEROSCLEROSISR01HL094470 · NHLBI · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M · 2009 to 2010
$1.4M
Molecular Imaging of Angiogenesis by MRIR01EB001704 · NIBIB · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M · 2004 to 2007
$946k
NCI NIH HHS CA-119342NCI NIH HHS U54 CA119342NHLBI NIH HHS HL094470NHLBI NIH HHS HL-73646NHLBI NIH HHS HL-78631NHLBI NIH HHS R01 HL073646NHLBI NIH HHS R01 HL078631NHLBI NIH HHS R01 HL094470NIBIB NIH HHS R01 EB001704NINDS NIH HHS R01 NS059302
6 · The paper itself

Abstract

Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomical descriptions to complicated phenotypic characterizations based upon the recognition of unique cell-surface biochemical signatures. Although originally the purview of nuclear medicine, "molecular imaging" is now studied in conjunction with all clinically relevant imaging modalities. Of the myriad of particles that have emerged as prospective candidates for clinical translation, perfluorocarbon nanoparticles offer great potential for combining targeted imaging with drug delivery, much like the "magic bullet" envisioned by Paul Ehrlich 100 years ago. Perfluorocarbon nanoparticles, once studied in Phase III clinical trials as blood substitutes, have found new life for molecular imaging and drug delivery. The particles have been adapted for use with all clinically relevant modalities and for targeted drug delivery. In particular, their intravascular constraint due to particle size provides a distinct advantage for angiogenesis imaging and antiangiogenesis therapy. As perfluorocarbon nanoparticles have recently entered Phase I clinical study, this review provides a timely focus on the development of this platform technology and its application for angiogenesis-related pathologies.

Indexed as

FluorocarbonsNanoparticlesAnimalsAtherosclerosisDiagnostic ImagingEmulsionsHumansNeoplasmsNeovascularization, PathologicEmulsionsFluorocarbons

Identifiers

PMID20411320
PMCPMC3140871

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.