ArticleJournal of neuro-oncology2010
Gamma Knife robotic microradiosurgery of pituitary adenomas invading the cavernous sinus: treatment concept and results in 89 cases.
Article in Journal of neuro-oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The safety and efficacy of robotic radiosurgery and radiotherapy in the management of skull base tumors: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Stereotactic radiosurgery for non-functioning pituitary adenomas: meta-analysis and International Stereotactic Radiosurgery Society practice opinion.Neuro-oncology · 2020Pooled it
- Pooled it
- Reconsideration of Surgical Indication for Prolactin-producing Pituitary Tumor Focusing on Visual Impairment.Neurologia medico-chirurgica · 2024Article
- Long-term hormonal and imaging outcomes of adjunctive gamma knife radiosurgery in non-functioning pituitary adenomas: a single center experience.Journal of neuro-oncology · 2022Article
- Review
- Early versus late Gamma Knife radiosurgery following transsphenoidal surgery for nonfunctioning pituitary macroadenomas: a multicenter matched-cohort study.Journal of neurosurgery · 2018Article
- Management of nonfunctioning pituitary tumors: radiotherapy.Pituitary · 2018Review
- Target delineation and optimal radiosurgical dose for pituitary tumors.Radiation oncology (London, England) · 2016Review
- Extended transsphenoidal approach for pituitary adenomas invading the cavernous sinus using multiple complementary techniques.Pituitary · 2016Article
- Clinical and Radiologic Outcome of Gamma Knife Radiosurgery on Nonfunctioning Pituitary Adenomas.Journal of neurological surgery. Part B, Skull base · 2015Article
- Cranial stereotactic radiosurgery: current status of the initial paradigm shifter.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Review
- Unyielding progress: recent advances in the treatment of central nervous system neoplasms with radiosurgery and radiation therapy.Journal of neuro-oncology · 2014Review
- Treatment paradigms for pituitary adenomas: defining the roles of radiosurgery and radiation therapy.Journal of neuro-oncology · 2014Review
- Advanced Image Coregistration within the Leksell Workstation for the Planning of Glioma Surgery: Initial Experience.Journal of neurological surgery reports · 2013Article
- Gamma knife stereotactic radiosurgery for drug resistant or intolerant invasive prolactinomas.Pituitary · 2013Article
- Stereotactic Irradiation of GH-Secreting Pituitary Adenomas.International journal of endocrinology · 2012Article
- Radiation techniques for acromegaly.Radiation oncology (London, England) · 2011Review
- Stereotactic radiosurgery in pituitary adenomas: long-term single institution experience and role of the hypothalamic-pituitary axis.Journal of radiosurgery and SBRT · 2011Article
- STEREOTACTIC RADIATION THERAPY IN PITUITARY ADENOMAS, IS IT BETTER THAN CONVENTIONAL RADIATION THERAPY?Acta endocrinologica (Bucharest, Romania : 2005)Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the present retrospective study was evaluation of results of "robotic microradiosurgery" of pituitary adenomas invading the cavernous sinus. Eighty-nine patients with such tumors underwent management using Leksell Gamma Knife model C with automatic positioning system. There were 77 residual and 12 recurrent neoplasms. The applied radiosurgical treatment plan was based on the use of multiple isocenters, mainly of smaller size, which were positioned compactly within the border of the lesion with resultant improved dose homogeneity, increased average dose within the target, and sharp dose fall outside the treated volume. The marginal dose varied from 12 to 25 Gy (mean, 18.2 Gy) in non-functional pituitary adenomas (43 cases), and from 12 to 35 Gy (mean, 25.2 Gy) in hormone-secreting ones (46 cases). The length of follow-up after treatment ranged from 24 to 76 months (mean, 36 months). Control of the tumor growth was attained in 86 cases (97%), whereas actual shrinkage of the lesion was marked in 57 cases (64%). In 18 out of 46 secreting neoplasms (39%), normalization of the excess of the pituitary hormone production was noted after radiosurgery. Treatment-associated morbidity was limited to transitory cranial nerve palsy in two patients (2%). No patient with either non-functional or hormone secreting tumor exhibited new pituitary hormone deficit after treatment. In conclusion, highly precise microanatomy-based Gamma Knife robotic microradiosurgery provides an opportunity for effective management of pituitary adenomas invading the cavernous sinus with preservation of the adjacent functionally important neuronal structures.
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Registered trials
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