Evidence map›Paper›PMID 20411255›Full record

ArticlePediatric radiology2010

Neonatal encephalopathy: a prospective comparison of head US and MRI.

Monica Epelman, Alan Daneman, Christian J Kellenberger, Abdul Aziz, Osnat Konen, Rahim Moineddin, Hilary Whyte, Susan Blaser

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03476343 (Clinical Use of a Neonatal MRI System), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03476343 nacompletednot on this mapstarted 2018, after this paper: background citation

Clinical Use of a Neonatal MRI System

TypeinterventionalSponsorChildren's Hospital Medical Center, CincinnatiRan2018 to 2022Enrolled386ConditionsNICU MRIArmsGE OPTIMA MR430s with HDx/GE Electronics
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Neuroimaging in the term newborn with neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021
    Review
  7. Article
  8. Cranial ultrasound for beginners.Translational pediatrics · 2021
    Review
  9. Review
  10. Review
  11. Article
  12. Ultrasound Predicts White Matter Integrity after Hypothermia Therapy in Neonatal Hypoxic-Ischemic Injury.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2019
    Article
  13. Imaging the term neonatal brain.Paediatrics & child health · 2018
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Monica EpelmanDepartment of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave, Toronto, Canada.
Alan Daneman
Christian J Kellenberger
Abdul Aziz
Osnat Konen
Rahim Moineddin
Hilary Whyte
Susan Blaser
Hospital for Sick Children · CAUniversity Children's Hospital Zurich · CHUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHead US, the cornerstone neuroimaging modality in neonates, is believed to be less sensitive than MRI for detecting hypoxic ischemic injury (HII). Most reports comparing these modalities are retrospective and have a long interval between the exams.

objectiveTo prospectively characterize the range of abnormalities found in US examinations performed within 2 h of brain MRI in encephalopathic neonates. MATERIALS AND

methodsA total of 76 consecutive exams met our inclusion criteria. Diagnostic performance of the US images was prospectively compared with MRI.

resultsMRI was considered positive for HII in 53 neonates. Of the remaining 23, MRI was negative for HII in 9, showed white matter abnormalities unrelated to HII in 8, and was inconclusive in 6. Of the 70 neonates with conclusive examinations, the US exam was regarded as positive in 67. Diagnostic accuracy of US was 95.7%.

conclusionOur study demonstrates that US should still be regarded as a screening test in neonates. US is more sensitive for the detection of injury than previously reported, and more attention should be paid to proper US technique. MRI shows disease more extensively and should be accomplished as early as possible.

Indexed as

Magnetic Resonance ImagingUltrasonographyBrain Injury, ChronicFemaleHeadHumansInfant, NewbornMaleProspective StudiesSensitivity and Specificity

Identifiers

PMID20411255
OpenAlexW2047016727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.