ArticlePediatric cardiology2010
No demonstrable effect of benzathine penicillin on recurrence of rheumatic Fever in pacific island population.
Article in Pediatric cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- The Effect of Secondary Prophylaxis Adherence on Rheumatic Heart Disease and Determinants of Poor Adherence in Children: A 10-Year Retrospective Cohort Study.Pediatric cardiology · 2026Article
- How Many Doses Make a Difference? An Analysis of Secondary Prevention of Rheumatic Fever and Rheumatic Heart Disease.Journal of the American Heart Association · 2018Article
- Adherence to Secondary Prophylaxis for Acute Rheumatic Fever and Rheumatic Heart Disease: A Systematic Review.Current cardiology reviews · 2017Article
- Throat culture positivity rate and antibiotic susceptibility pattern of beta-hemolytic streptococci in children on secondary prophylaxis for rheumatic heart disease.BMC infectious diseases · 2016Article
- Of history, half-truths, and rheumatic fever.Annals of pediatric cardiology · 2013Article
- Determinants of poor adherence to secondary antibiotic prophylaxis for rheumatic fever recurrence on Lifou, New Caledonia: a retrospective cohort study.BMC public health · 2013Article
- Secondary prophylaxis is important for the prevention of recurrent rheumatic fever in the Pacific.Pediatric cardiology · 2011Article
- Benzathine penicillin for recurrence of rheumatic fever: the jury is still out.Pediatric cardiology · 2011Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compliance with secondary antibiotic prophylaxis for acute rheumatic fever (ARF) should decrease the rate of recurrence; however, efficacy in a highly endemic area has not been studied. A retrospective chart review of patients <21 years old with a diagnosis of ARF in the Northern Mariana Islands was performed. Patient compliance with benzathine penicillin G (BPG) prophylaxis was assessed. One hundred forty-four patients with ARF were identified and considered eligible, and the recurrence rate was 38%. Mean level of compliance with BPG was 59% in patients with no recurrence of ARF and 57% in patients with recurrence of ARF. Level of compliance was not shown to be associated with odds of recurrence. There was a trend toward significance (p = 0.06), with those patients who had carditis at the time of diagnosis of ARF having higher odds of recurrence. A remarkably high recurrence rate of ARF was found in this population, but there was no difference in compliance with secondary antibiotic prophylaxis between those with and without recurrence of ARF. These findings stress the need to improve methods of primary prevention and secondary antibiotic prophylaxis for ARF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.