ReviewMarine drugs2010
Synthesis of marine polycyclic polyethers via endo-selective epoxide-opening cascades.
Review in Marine drugs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Ring opening of epoxides: a facile approach towards the synthesis of polyketides and related stereoenriched natural products: a review.Molecular diversity · 2025Review
- Exploring the synthetic potential of epoxide ring opening reactions toward the synthesis of alkaloids and terpenoids: a review.RSC advances · 2024Review
- Cooperative Bifurcated Chalcogen Bonding and Hydrogen Bonding as Stereocontrolling Elements for Selective Strain-Release Septanosylation.Journal of the American Chemical Society · 2023Article
- Theoretical Study on the Origin of Abnormal Regioselectivity in Ring-Opening Reaction of Hexafluoropropylene Oxide.Molecules (Basel, Switzerland) · 2023Article
- Natural Polyether Ionophores and Their Pharmacological Profile.Marine drugs · 2022Review
- Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans.Organic & biomolecular chemistry · 2022Review
- Constrained Dipeptide Surrogates: 5- and 7-Hydroxy Indolizidin-2-one Amino Acid Synthesis from Iodolactonization of Dehydro-2,8-diamino Azelates.Molecules (Basel, Switzerland) · 2021Article
- Influence of the Substituents on the Opening of Silylepoxy Alcohols: 5-Molecules (Basel, Switzerland) · 2021Article
- Synthesis of theOrganic letters · 2019Article
- Synthesis of the ABC framework of tamulamides A and B.Bioorganic & medicinal chemistry · 2018Article
- Natural products as inspiration for the development of new synthetic methods.Journal of the Chinese Chemical Society. Zhongguo hua xue hui (Taipei, Taiwan) · 2018Article
- The Oxepane Motif in Marine Drugs.Marine drugs · 2017Review
- Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.Journal of ginseng research · 2017Review
- Article
- Hydroxyl-substituted ladder polyethers via selective tandem epoxidation/cyclization sequence.Organic letters · 2015Article
- A dioxane template for highly selective epoxy alcohol cyclizations.Chemistry (Weinheim an der Bergstrasse, Germany) · 2013Article
- Cascade approach to stereoselective polycyclic ether formation: epoxides as trapping agents in the transposition of allylic alcohols.Angewandte Chemie (International ed. in English) · 2013Article
- Lessons and revelations from biomimetic syntheses.Nature chemical biology · 2011Article
- Total synthesis of the protein phosphatase 2A inhibitor lactodehydrothyrsiferol.Angewandte Chemie (International ed. in English) · 2011Article
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proposed biosynthetic pathways to ladder polyethers of polyketide origin and oxasqualenoids of terpenoid origin share a dramatic epoxide-opening cascade as a key step. Polycyclic structures generated in these biosynthetic pathways display biological effects ranging from potentially therapeutic properties to extreme lethality. Much of the structural complexity of ladder polyether and oxasqualenoid natural products can be traced to these hypothesized cascades. In this review we summarize how such epoxide-opening cascade reactions have been used in the synthesis of ladder polyethers and oxasqualenoid natural products.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.