ArticleJournal of perinatology : official journal of the California Perinatal Association2010
Increasing platelets without transfusion: is it time to introduce novel thrombopoietic agents in neonatal care?
Article in Journal of perinatology : official journal of the California Perinatal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 28 citations in OpenAlex.
- Thrombopoietin receptor agonist for treatment of immune thrombocytopenia in pregnancy: a narrative review.Therapeutic advances in hematology · 2021Review
- Understanding thrombocytopenia: physiological role of microRNA in survival of neonatal megakaryocytes.Journal of thrombosis and thrombolysis · 2015Article
- Thrombocytopenia in Small-for-Gestational-Age Infants.Pediatrics · 2015Article
- Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates.American journal of physiology. Heart and circulatory physiology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Food and Drug Administration recently approved two novel thrombopoiesis-stimulating agents, Romiplostim (AMG-531, Nplate) and Eltrombopag (Promacta), for the treatment of adults with immune thrombocytopenic purpura. For physicians taking care of critically ill neonates, this offers the opportunity of decreasing platelet transfusions and potentially improving the outcomes of neonates with severe and prolonged thrombocytopenia. However, several developmental factors need to be taken into consideration. First, the population of thrombocytopenic neonates likely to benefit from these agents needs to be carefully selected. Second, the mechanisms underlying neonatal and adult thrombocytopenia differ from each other and are incompletely understood, and pre-clinical evidence suggests that the response of neonates to thrombopoietic factors might be different from that of adults. Finally, the potential non-hematopoietic effects of thrombopoietin have not been well established. Here, we will discuss these issues in detail, and will highlight the critical developmental differences between neonates and adults that need to be considered as we think about introducing these agents into neonatal care.
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Registered trials
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