Evidence map›Paper›PMID 20410904›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2011

Role of probiotics in the prevention of the enteric colonization by Candida in preterm newborns: incidence of late-onset sepsis and neurological outcome.

M G Romeo, D M Romeo, L Trovato, S Oliveri, F Palermo, F Cota, P Betta

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05945017 (Probiotics and the Neurodevelopment in the Premature Infant <32 Weeks Gestational Age and <1500g), which is not on this map. Cited by 73 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 21 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05945017 naactive not recruitingnot on this mapstarted 2014, after this paper: background citation

Probiotics and the Neurodevelopment in the Premature Infant <32 Weeks Gestational Age and <1500g

TypeinterventionalSponsorFundacion Clinic per a la Recerca BiomédicaRan2014 to 2027Enrolled233ConditionsInfant, Newborn, Diseases, Infant DevelopmentArmsInfloran® -Berne, Switzerland- (Bifidobacterium bifidum NCDO 2203 and Lactobacillus acidophilus NCDO 1748
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 21 syntheses or guidelines pooled it.

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  3. Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  16. Systematic Review of the Effect of Enteral Feeding on Gut Microbiota in Preterm Infants.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2018
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M G RomeoNeonatal Intensive Care Unit, University of Catania, Catania, Italy.
D M Romeo
L Trovato
S Oliveri
F Palermo
F Cota
P Betta

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the efficacy of probiotics in the prevention of gastrointestinal colonization by Candida species, of late-onset sepsis and neurological outcome in preterm newborns. STUDY

designA prospective study was conducted in 249 preterms who were subdivided into three groups: one group (n=83) was supplemented with Lactobacillus (L.) reuteri, one group with L. rhamnosus (n=83) and the other with no supplementation (n=83). The fungal colonization in the gastrointestinal tract, the late onset of sepsis and clinical parameters were recorded. A neurological structured assessment was further performed at 1 year of age.

resultCandida stool colonization was significantly higher (P<0.01) in the control group than in the groups treated with probiotics. The L. reuteri group presented a significantly higher reduction in gastrointestinal symptoms than did the L. rhamnosus and control groups. Infants treated with probiotics showed a statistically significant lower incidence of abnormal neurological outcome than did the control group.

conclusionThe use of both probiotics seems to be effective in the prevention of gastrointestinal colonization by Candida, in the protection from late-onset sepis and in reducing abnormal neurological outcomes in preterms.

Indexed as

Infant, PrematureCandidiasisFemaleGastrointestinal DiseasesHumansIncidenceInfant, NewbornIntensive Care Units, NeonatalLacticaseibacillus rhamnosusLimosilactobacillus reuteriMaleMycosesNervous System DiseasesNeurologic ExaminationProbioticsProspective Studies

Identifiers

PMID20410904
PMCPMC3016918

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.