ArticleJournal of the American Academy of Child and Adolescent Psychiatry2010
Pediatric bipolar disorder versus severe mood dysregulation: risk for manic episodes on follow-up.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Evidence-based treatments for youths with severely dysregulated mood: a qualitative systematic review of trials for SMD and DMDD.European child & adolescent psychiatry · 2017Pooled it
- The Status of Irritability in Psychiatry: A Conceptual and Quantitative Review.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Pooled it
- Irritability in Children and Adolescents With OCD.Behavior therapy · 2021Trial
- A Double-Blind Randomized Placebo-Controlled Trial of Citalopram Adjunctive to Stimulant Medication in Youth With Chronic Severe Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Trial
- A novel group therapy for children with ADHD and severe mood dysregulation.Journal of attention disorders · 2013Trial
- Expert Rater Agreement for Symptoms and Diagnosis of Bipolar Disorder in Youth.Child psychiatry and human development · 2026Article
- Characterizing Early Childhood Disruptive Mood Dysregulation Disorder.JAACAP open · 2026Article
- Comparing Youth With Bipolar Disorder to Non-Bipolar Youth Referred for Bipolar Disorder.JAACAP open · 2025Article
- Pediatric Bipolar Disorder: A Practical Guide for Clinicians.Child psychiatry and human development · 2025Article
- Irritability in Mood Disorders: Neurobiological Underpinnings and Implications for Pharmacological Intervention.CNS drugs · 2021Review
- Disruptive Mood Dysregulation Disorder: Symptomatic and Syndromic Thresholds and Diagnostic Operationalization.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Annual Research Review: Defining and treating pediatric treatment-resistant depression.Journal of child psychology and psychiatry, and allied disciplines · 2020Review
- Accelerated cortical thinning within structural brain networks is associated with irritability in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Progress in diagnosis and treatment of bipolar disorder among children and adolescents: an international perspective.Evidence-based mental health · 2018Review
- Comparing the DSM-5 construct of Disruptive Mood Dysregulation Disorder and ICD-10 Mixed Disorder of Emotion and Conduct in the UK Longitudinal Assessment of Manic Symptoms (UK-LAMS) Study.European child & adolescent psychiatry · 2018Article
- Irritability in Youths: A Translational Model.The American journal of psychiatry · 2017Review
- Irritability in Children and Adolescents.Annual review of clinical psychology · 2017Review
- Pediatric Mania: The Controversy between Euphoria and Irritability.Current neuropharmacology · 2017Review
- Comparing Brain Morphometry Across Multiple Childhood Psychiatric Disorders.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveAn important question in pediatric bipolar research is whether marked nonepisodic irritability is a manifestation of bipolar disorder in youth. This study tests the hypothesis that youth with severe mood dysregulation (SMD), a category created for the purpose of studying children presenting with severe nonepisodic irritability, will be significantly less likely to develop (hypo-)manic or mixed episodes over time than will youth with bipolar disorder (BD).
methodPatients with SMD (N = 84) and narrowly defined BD (N = 93) at baseline were followed up in 6-monthly intervals using the relevant K-SADS modules to ascertain (hypo-)manic or mixed episodes.
resultsOnly one of 84 SMD subjects (1/84 [1.2%]; 95% confidence interval CI = 0.0003 to 0.064) experienced a (hypo-)manic or mixed episode during the study (median follow-up = 28.7 months). The frequency of such episodes was more than 50 times higher in those with narrowly defined BD (58/93 [62.4%]; 95% CI 0.52 to 0.72).
conclusionsThese data suggest that, over an approximately 2-year follow-up period, youth with SMD are unlikely to develop (hypo-)manic or mixed episodes.
Indexed as
Identifiers
20410732PMC3000433W2119222953What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.