ArticleJournal of the American Academy of Child and Adolescent Psychiatry2010
Familial clustering and DRD4 effects on electroencephalogram measures in multiplex families with attention deficit/hyperactivity disorder.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
- Validity of DSM-IV attention deficit/hyperactivity disorder symptom dimensions and subtypes.Journal of abnormal psychology · 2012Pooled it
- Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder.Expert reviews in molecular medicine · 2011Pooled it
- Effects of d-Methylphenidate, Guanfacine, and Their Combination on Electroencephalogram Resting State Spectral Power in Attention-Deficit/Hyperactivity Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Trial
- A Network Approach to Understanding the Role of Executive Functioning and Alpha Oscillations in Inattention and Hyperactivity-Impulsivity Symptoms of ADHD.Journal of attention disorders · 2024Article
- Alpha event-related decreases during encoding in adults with ADHD - An investigation of sustained attention and working memory processes.Behavioural brain research · 2024Article
- Eyes-closed versus eyes-open differences in spontaneous neural dynamics during development.NeuroImage · 2022Article
- Preliminary Real-World Evidence Supporting the Efficacy of a Remote Neurofeedback System in Improving Mental Health: Retrospective Single-Group Pretest-Posttest Study.JMIR formative research · 2022Article
- Alpha-band power increases in posterior brain regions in attention deficit hyperactivity disorder after digital cognitive stimulation treatment: randomized controlled study.Brain communications · 2022Article
- Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?Frontiers in psychology · 2022Review
- Disrupted Functional Rich-Club Organization of the Brain Networks in Children with Attention-Deficit/Hyperactivity Disorder, a Resting-State EEG Study.Brain sciences · 2021Article
- Quantitative EEG features selection in the classification of attention and response control in the children and adolescents with attention deficit hyperactivity disorder.Future science OA · 2018Article
- EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes.Brain topography · 2018Article
- Parsing heterogeneity in attention-deficit hyperactivity disorder using EEG-based subgroups.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
- Aberrant Modulation of Brain Oscillatory Activity and Attentional Impairment in Attention-Deficit/Hyperactivity Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Review
- Frontal theta/beta ratio changes during TOVA in Egyptian ADHD children.Neurosciences (Riyadh, Saudi Arabia) · 2017Article
- DRD4 Variants Moderate the Impact of Parental Characteristics on Child Attention-Deficit Hyperactivity Disorder: Exploratory Evidence from a Multiplex Family Design.Journal of abnormal child psychology · 2017Article
- Research Review: Use of EEG biomarkers in child psychiatry research - current state and future directions.Journal of child psychology and psychiatry, and allied disciplines · 2016Review
- A Matter of Time: The Influence of Recording Context on EEG Spectral Power in Adolescents and Young Adults with ADHD.Brain topography · 2015Article
- A parietal biomarker for ADHD liability: as predicted by the distributed effects perspective model of ADHD.Frontiers in psychiatry · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveThe current study tests electroencephalogram (EEG) measures as a potential endophenotype for attention deficit/hyperactivity disorder (ADHD) by examining sibling and parent-offspring similarity, familial clustering with the disorder, and association with the dopamine receptor D4 (DRD4) candidate gene.
methodThe sample consists of 531 participants (191 parents and 340 children) from 132 multiplex families with ADHD who participated in a larger genetics study. All members of the families underwent extensive assessment including semi-structured diagnostic interviews and EEG recording.
resultsStrong sibling similarity and parent-offspring correlations in EEG power emerged, suggesting high trait heritability. Increased theta power was observed among children with ADHD when compared with unaffected children, and there were no differences according to ADHD subtype. Within the parent sample, ADHD diagnostic status and ADHD subtype group differences emerged in the theta, alpha, and beta frequency bands. DRD4 effects for both parents and children were apparent in the beta frequency band and for children only in the theta frequency band.
conclusionsThis study suggests that EEG measures are a promising avenue of study in the search for putative endophenotypes for ADHD, and that variability at the DRD4 gene may contribute to this endophenotype.
Indexed as
Identifiers
20410729PMC2919766What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.