SynthesisThe New England journal of medicine2010
Failure to validate association between 12p13 variants and ischemic stroke.
Open access · bronzeAbstract readLetterMeta-AnalysisComment
In one paragraph
Synthesis in The New England journal of medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 5 pooled it
9.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Guideline
- Pooled it
- Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.The Lancet. Neurology · 2012Pooled it
- The effect of survival bias on case-control genetic association studies of highly lethal diseases.Circulation. Cardiovascular genetics · 2011Pooled it
- Genomic risk profiling of ischemic stroke: results of an international genome-wide association meta-analysis.PloS one · 2011Pooled it
- The relationship between the prognosis of children with acute arterial stroke and polymorphisms of CDKN2B, HDAC9, NINJ2, NAA25 genes.Journal of thrombosis and thrombolysis · 2019Trial
- TTC7B emerges as a novel risk factor for ischemic stroke through the convergence of several genome-wide approaches.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Trial
- Alternative Splicing of Putative Stroke/Vascular Risk Factor Genes Expressed in Blood Following Ischemic Stroke Is Sexually Dimorphic and Cause-Specific.Frontiers in neurology · 2020Article
- Article
- A Novel Functional Polymorphism in the NINJ2 Promoter Predicts Risk of Large Artery Atherosclerotic Stroke.Molecular neurobiology · 2016Article
- Genetic Risk Factors for Ischemic and Hemorrhagic Stroke.Current cardiology reports · 2016Review
- Towards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol.BMJ open · 2016Article
- Genome-wide association studies of late-onset cardiovascular disease.Journal of molecular and cellular cardiology · 2015Review
- Mechanisms and treatment of ischaemic stroke--insights from genetic associations.Nature reviews. Neurology · 2014Review
- Genome-wide association studies in neurology.Annals of translational medicine · 2014Review
- Genetics of ischemic stroke in young adults.Circulation. Cardiovascular genetics · 2014Review
- Recent mitochondrial DNA mutations increase the risk of developing common late-onset human diseases.PLoS genetics · 2014Article
- Two novel susceptibility SNPs for ischemic stroke using exome sequencing in Chinese Han population.Molecular neurobiology · 2014Article
- Clinical neurogenetics: stroke.Neurologic clinics · 2013Review
- Genetic profiles in ischaemic stroke.Current atherosclerosis reports · 2013Review
Corrections and comments
- Comment on
Authors and funding
2 authors.
International Stroke Genetics Consortium
Wellcome Trust Case-Control Consortium 2
Funding
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MSTROKE INCIDENCE AND OUTCOME AMONG BLACKS AND WHITESR01NS030678 · NINDS · UNIVERSITY OF CINCINNATI · PI KISSELA, BRETT M, KLEINDORFER, DAWN O · 1993 to 2024
$26.7MPharmacogenomics and Risk of Cardiovascular DiseaseU01HL069757 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KRAUSS, RONALD M · 2001 to 2009
$24.7MVitamin Intervention for Stroke Prevention (VISP)R01NS034447 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TOOLE, JAMES F · 1996 to 2006
$18.0MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MAN NCRR CENTER FOR HIGH THROUGHPUT SNP GENOTYPING AND ANALYSIS: GAIN NETWORKU54RR020278 · NCRR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2004 to 2008
$14.4MGenetic&Environment Risk Factors for Hemorrhagic StrokeR01NS036695 · NINDS · UNIVERSITY OF CINCINNATI · PI WOO, DANIEL · 1997 to 2012
$14.1MPharmacogenomics and Risk of Cardiovascular DiseaseU19HL069757 · NHLBI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI KRAUSS, RONALD M · 2010 to 2014
$12.8MGenetic and Environmental Risk Factors for Hemorrhagic StrokeU01NS036695 · NINDS · UNIVERSITY OF CINCINNATI · PI ROSAND, JONATHAN, WOO, DANIEL · 2016 to 2020
$7.0MA Genome-wide Association Study for Early-Onset Myocardial InfarctionR01HL087676 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ALTSHULER, DAVID · 2007 to 2009
$4.7MGene Discovery for Warfarin-Related Intracerebral HemorrhageR01NS059727 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROSAND, JONATHAN · 2008 to 2012
$4.2MBiotechnology and Biological Sciences Research Council BB/F019394/1British Heart Foundation RG/08/014/24067Intramural NIH HHSMedical Research Council G0000934Medical Research Council G0700704Medical Research Council G0701075Medical Research Council G0800509NCI NIH HHS CA 047988NCRR NIH HHS M01 RR07122NCRR NIH HHS M01 RR 165001NCRR NIH HHS R54 RR020278NHGRI NIH HHS U01 HG004436NHLBI NIH HHS HL 043851NHLBI NIH HHS HL69757NHLBI NIH HHS R01 HL087676NHLBI NIH HHS R25 HL088724NIDDK NIH HHS P30 DK072488NINDS NIH HHS 1R01 NS059727NINDS NIH HHS K08 NS045802NINDS NIH HHS NS056302NINDS NIH HHS NS30678NINDS NIH HHS NS34447NINDS NIH HHS NS36695NINDS NIH HHS R01 NS059727NINDS NIH HHS R01 NS 42733NINDS NIH HHS R01 NS45012NINDS NIH HHS R21NS064908PHS HHS P60 12583Wellcome Trust 068545/Z/02
Abstract
PubMed holds no abstract for this paper.
Indexed as
Polymorphism, Single NucleotideAsian PeopleBlack PeopleBrain IschemiaChromosomes, Human, Pair 12False Positive ReactionsGene ExpressionHumansStrokeWhite People
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.