ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Allergic conjunctivitis exacerbates corneal allograft rejection by activating Th1 and th2 alloimmune responses.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- The role of impaired bone marrow Tregs in hematopoietic stem cell depletion for pediatric aplastic anemia probably involves immune privilege.Blood research · 2026Article
- A mouse model of allergic conjunctivitis with mucosal immune-related gene and circRNA dysregulation.Frontiers in immunology · 2026Article
- Case Report: A Case of Acute Cellular Rejection Due to Atopic Dermatitis Exacerbation 3 Years After Heart Transplantation.Frontiers in immunology · 2021Article
- Animal models of high-risk corneal transplantation: A comprehensive review.Experimental eye research · 2020Review
- Immune Privilege and Eye-Derived T-Regulatory Cells.Journal of immunology research · 2018Review
- Immunology of Corneal Allografts: Insights from Animal Models.Journal of clinical & experimental ophthalmology · 2015Article
- Protection by LPS-induced inhibitory CD11b(+) cells on corneal allograft.International journal of clinical and experimental medicine · 2015Article
- IFN-γ blocks CD4+CD25+ Tregs and abolishes immune privilege of minor histocompatibility mismatched corneal allografts.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Allergic conjunctivitis: a comprehensive review of the literature.Italian journal of pediatrics · 2013Review
- New twists to an old story: novel concepts in the pathogenesis of allergic eye disease.Current eye research · 2013Review
- Corneal transplantation and immune privilege.International reviews of immunology · 2013Review
- Gamma-irradiation reduces the allogenicity of donor corneas.Investigative ophthalmology & visual science · 2012Article
- Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis.Recent patents on inflammation & allergy drug discovery · 2011Review
- Paradigm shifts in the role of CD4+ T cells in keratoplasty.Discovery medicine · 2010Article
- High-risk corneal allografts and why they lose their immune privilege.Current opinion in allergy and clinical immunology · 2010Review
- Ocular surgical models for immune and angiogenic responses.Journal of biological methodsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Allergic conjunctivitis (AC) and airway hyperreactivity exacerbate corneal allograft rejection. Because AC and airway hyperreactivity are allergic diseases of mucosal tissues, we determined whether an allergic disease of a nonmucosal tissue would affect corneal allograft rejection and whether Th2 cells alone accounted for accelerated graft rejection in allergic mice. Hosts sensitized cutaneously with short ragweed pollen developed cutaneous immediate hypersensitivity but rejected corneal allografts at the same tempo and incidence as naive mice. Th2 immune deviation induced with keyhole limpet hemocyanin and IFA did not affect corneal allograft rejection. Thus, Th2 immune deviation alone does not account for the exacerbation of corneal allograft rejection that occurs in mice with AC. CD4(+) T cells from AC mice elaborated Th1 (IFN-gamma) and Th2 (IL-13) cytokines when challenged with donor alloantigens. Adoptive transfer of Th1 or Th2 cells to nude mice, from AC mice that had rejected corneal allografts, produced graft rejection in 70% and 20% of the hosts, respectively. In contrast, adoptive transfer of a combination of Th1 and Th2 cells produced 100% rejection. Administration of exogenous IFN-gamma could substitute for Th1 cells and produced 100% corneal allograft rejection in recipients of Th2 cells alone. By contrast, IFN-gamma did not significantly enhance corneal allograft rejection mediated by Th1 cells. Thus, exacerbation of corneal allograft rejection in mice with AC is associated with a mixed Th1 and Th2 alloimmune response, and the contribution of Th1 cells is through their production of IFN-gamma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.