ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Early life stress downregulates endothelin receptor expression and enhances acute stress-mediated blood pressure responses in adult rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Progressive exercise training improves cardiovascular psychophysiological outcomes in young adult women with a history of adverse childhood experiences.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review.Frontiers in public health · 2024Review
- Endothelin Modulates Rhythm Disturbances and Autonomic Responses to Acute Emotional Stress in Rats.Biology · 2023Article
- The Involvement of Endothelin Pathway in Chronic Psychological Stress-Induced Bladder Hyperalgesia Through Capsaicin-Sensitive C-Fiber Afferents.Journal of inflammation research · 2022Article
- Crosstalk Among NLRP3 Inflammasome, ETNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and CystathionineOxidative medicine and cellular longevity · 2020Article
- Elevated plasma endothelin-1 is associated with reduced weight loss post vertical sleeve gastrectomy.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2019Article
- Childhood adversity and mechanistic links to hypertension risk in adulthood.British journal of pharmacology · 2019Review
- Early life stress induces immune priming in kidneys of adult male rats.American journal of physiology. Renal physiology · 2018Article
- Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium-Derived Endothelin-1.Journal of the American Heart Association · 2018Article
- Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents.Neuroscience and biobehavioral reviews · 2017Review
- Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress.American journal of physiology. Endocrinology and metabolism · 2017Article
- Role of the endothelin system in sexual dimorphism in cardiovascular and renal diseases.Life sciences · 2016Review
- Independent effects of early-life experience and trait aggression on cardiovascular function.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- High Prevalence of Insecure Attachment in Patients with Primary Hypertension.Frontiers in psychology · 2016Article
- Sex-Specific Effect of Endothelin in the Blood Pressure Response to Acute Angiotensin II in Growth-Restricted Rats.Hypertension (Dallas, Tex. : 1979) · 2015Article
- The roles of sensitization and neuroplasticity in the long-term regulation of blood pressure and hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- The role of adverse childhood experiences in cardiovascular disease risk: a review with emphasis on plausible mechanisms.Current cardiology reports · 2015Review
- Is birth a critical period in the pathogenesis of autism spectrum disorders?Nature reviews. Neuroscience · 2015Review
- Adverse childhood experiences and blood pressure trajectories from childhood to young adulthood: the Georgia stress and Heart study.Circulation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We hypothesized that early life stress enhances endothelin (ET-1)-dependent acute stress responses in adulthood. We utilized a unique rat model, wild-type (WT) and ET(B) receptor-deficient spotting lethal (sl/sl) rats, as well as pharmacological blockade of ET receptors, in a model of early life stress, maternal separation (MS). MS was performed in male WT and sl/sl rats 3 h/day from day 2 to 14 of life. Acute air jet stress (AJS)-induced responses (elevation in blood pressure, plasma corticosterone, and plasma ET-1) were evaluated in adult MS rats compared with the nonhandled littermate (control) rats. MS significantly augmented the acute AJS-induced blood pressure response (area under the curve) in WT rats compared with control, while the AJS-induced pressor responses were similar in sl/sl MS and control rats. ET receptor blockade significantly blunted the AJS-induced pressor response in WT MS and control rats. Moreover, AJS-induced plasma corticosterone levels in control rats were sensitive to ET receptor blockade, yet, AJS did not alter plasma corticosterone levels in MS rats. MS significantly increased circulating ET-1 levels, and AJS-induced plasma ET-1 levels were similarly increased in control and MS rats. MS induced a significant downregulation in expression of ET(A) and ET(B) receptors in aortic tissue compared with control rats. These results indicate that early life stress reduced expression of ET(A) and ET(B) receptors, leading to alterations in the ET pathway, and an exaggerated acute stress-mediated pressor response in adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.